Evidence map›Paper›PMID 39399565›Full record

ArticleNeurology. Clinical practice2025

Health Disparities Among Sexual and Gender Minority People Living With Epilepsy: A Cross-Sectional Analysis.

Levi C M Barros, Caroline Banfi, Julianne D Brooks, Maria A Donahue, Aya ElHassan, Chelsea N Wong, Z Paige L'Erario, Brandy E Fureman, Jeffrey Buchhalter, Sahar Zafar and 2 more

Abstract read
In one paragraph

Article in Neurology. Clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Sex and gender-related differences in neurological diseases: current challenges and recommendations for clinical practice.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Levi C M BarrosNeurology Department (LCMB, JDB, MAD, AE, SZ, LMVRM), Massachusetts General Hospital; Boston University School of Public Health (CB); Department of Medicine and Marcus Institute for Aging Research at HSL (CNW), Division of Gerontology at BIDMC, Harvard Medical School; Greenburgh Pride (ZPLE); LGBTQI Section, American Academy of Neurology; Epilepsy Foundation of America (BEF, AK); and Buchhalter Consulting (JB), PLLC.ORCID https://orcid.org/0000-0002-0502-068X
Caroline BanfiNeurology Department (LCMB, JDB, MAD, AE, SZ, LMVRM), Massachusetts General Hospital; Boston University School of Public Health (CB); Department of Medicine and Marcus Institute for Aging Research at HSL (CNW), Division of Gerontology at BIDMC, Harvard Medical School; Greenburgh Pride (ZPLE); LGBTQI Section, American Academy of Neurology; Epilepsy Foundation of America (BEF, AK); and Buchhalter Consulting (JB), PLLC.ORCID https://orcid.org/0009-0006-2217-7298
Julianne D BrooksNeurology Department (LCMB, JDB, MAD, AE, SZ, LMVRM), Massachusetts General Hospital; Boston University School of Public Health (CB); Department of Medicine and Marcus Institute for Aging Research at HSL (CNW), Division of Gerontology at BIDMC, Harvard Medical School; Greenburgh Pride (ZPLE); LGBTQI Section, American Academy of Neurology; Epilepsy Foundation of America (BEF, AK); and Buchhalter Consulting (JB), PLLC.ORCID https://orcid.org/0000-0002-7624-2423
Maria A DonahueNeurology Department (LCMB, JDB, MAD, AE, SZ, LMVRM), Massachusetts General Hospital; Boston University School of Public Health (CB); Department of Medicine and Marcus Institute for Aging Research at HSL (CNW), Division of Gerontology at BIDMC, Harvard Medical School; Greenburgh Pride (ZPLE); LGBTQI Section, American Academy of Neurology; Epilepsy Foundation of America (BEF, AK); and Buchhalter Consulting (JB), PLLC.ORCID https://orcid.org/0000-0002-5217-7794
Aya ElHassanNeurology Department (LCMB, JDB, MAD, AE, SZ, LMVRM), Massachusetts General Hospital; Boston University School of Public Health (CB); Department of Medicine and Marcus Institute for Aging Research at HSL (CNW), Division of Gerontology at BIDMC, Harvard Medical School; Greenburgh Pride (ZPLE); LGBTQI Section, American Academy of Neurology; Epilepsy Foundation of America (BEF, AK); and Buchhalter Consulting (JB), PLLC.ORCID https://orcid.org/0009-0001-6733-8466
Chelsea N WongNeurology Department (LCMB, JDB, MAD, AE, SZ, LMVRM), Massachusetts General Hospital; Boston University School of Public Health (CB); Department of Medicine and Marcus Institute for Aging Research at HSL (CNW), Division of Gerontology at BIDMC, Harvard Medical School; Greenburgh Pride (ZPLE); LGBTQI Section, American Academy of Neurology; Epilepsy Foundation of America (BEF, AK); and Buchhalter Consulting (JB), PLLC.ORCID https://orcid.org/0000-0003-4315-3923
Z Paige L'ErarioNeurology Department (LCMB, JDB, MAD, AE, SZ, LMVRM), Massachusetts General Hospital; Boston University School of Public Health (CB); Department of Medicine and Marcus Institute for Aging Research at HSL (CNW), Division of Gerontology at BIDMC, Harvard Medical School; Greenburgh Pride (ZPLE); LGBTQI Section, American Academy of Neurology; Epilepsy Foundation of America (BEF, AK); and Buchhalter Consulting (JB), PLLC.
Brandy E FuremanNeurology Department (LCMB, JDB, MAD, AE, SZ, LMVRM), Massachusetts General Hospital; Boston University School of Public Health (CB); Department of Medicine and Marcus Institute for Aging Research at HSL (CNW), Division of Gerontology at BIDMC, Harvard Medical School; Greenburgh Pride (ZPLE); LGBTQI Section, American Academy of Neurology; Epilepsy Foundation of America (BEF, AK); and Buchhalter Consulting (JB), PLLC.ORCID https://orcid.org/0000-0002-7862-4716
Jeffrey BuchhalterNeurology Department (LCMB, JDB, MAD, AE, SZ, LMVRM), Massachusetts General Hospital; Boston University School of Public Health (CB); Department of Medicine and Marcus Institute for Aging Research at HSL (CNW), Division of Gerontology at BIDMC, Harvard Medical School; Greenburgh Pride (ZPLE); LGBTQI Section, American Academy of Neurology; Epilepsy Foundation of America (BEF, AK); and Buchhalter Consulting (JB), PLLC.ORCID https://orcid.org/0000-0002-6807-8328
Sahar ZafarNeurology Department (LCMB, JDB, MAD, AE, SZ, LMVRM), Massachusetts General Hospital; Boston University School of Public Health (CB); Department of Medicine and Marcus Institute for Aging Research at HSL (CNW), Division of Gerontology at BIDMC, Harvard Medical School; Greenburgh Pride (ZPLE); LGBTQI Section, American Academy of Neurology; Epilepsy Foundation of America (BEF, AK); and Buchhalter Consulting (JB), PLLC.ORCID https://orcid.org/0000-0001-5252-5376
Alison KuklaNeurology Department (LCMB, JDB, MAD, AE, SZ, LMVRM), Massachusetts General Hospital; Boston University School of Public Health (CB); Department of Medicine and Marcus Institute for Aging Research at HSL (CNW), Division of Gerontology at BIDMC, Harvard Medical School; Greenburgh Pride (ZPLE); LGBTQI Section, American Academy of Neurology; Epilepsy Foundation of America (BEF, AK); and Buchhalter Consulting (JB), PLLC.ORCID https://orcid.org/0000-0003-2665-5542
Lidia M V R MouraNeurology Department (LCMB, JDB, MAD, AE, SZ, LMVRM), Massachusetts General Hospital; Boston University School of Public Health (CB); Department of Medicine and Marcus Institute for Aging Research at HSL (CNW), Division of Gerontology at BIDMC, Harvard Medical School; Greenburgh Pride (ZPLE); LGBTQI Section, American Academy of Neurology; Epilepsy Foundation of America (BEF, AK); and Buchhalter Consulting (JB), PLLC.ORCID https://orcid.org/0000-0002-1191-1315

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: Visibility of sexual and gender minority (SGM) people has been steadily increasing over the recent years; however, little is known about the distinct seizure and mental health characteristics among SGM people with epilepsy. In this study, we describe these characteristics among SGM subgroups. Methods: Data on demographics, seizure metrics, mental health, and quality of life were collected using patient-reported questionnaires gathered at first epilepsy clinic visits as part of routine clinical care from January 2019 to September 2023 at Massachusetts General Hospital. SGM people were defined as people who completed both sexual orientation and gender identity questionnaires and reported a sexual orientation other than heterosexual and/or a gender identity other than cisgender. Seizure control was defined as 1 year or more without experiencing seizures. Anxiety, depression, and quality-of-life data were collected through ordinal scales (GAD-7, PHQ-9, and PROMIS 10, respectively). Descriptive statistics were used to compare data between groups. No association test was performed because of the descriptive nature of this study. Results: From 4,046 first-visit questionnaires, 2,166 (53.53%) had sexual orientation and gender identity information, with 143 (6.6%) of these respondents identified as SGM. Seizure control was present in 27 (65.85%) and 401 (62.95%) heterosexual cisgender respondents. Median values of SGM and heterosexual cisgender respondents were 5 (interquartile range [IQR] 8) and 3 (IQR 6) for PHQ-9 (depression), 4 (IQR 7) and 3 (IQR 10) for GAD-7 (anxiety), 41.1 (IQR 14.5) and 45.8 (IQR 14.5) for PROMIS-10-Mental, and 47.7 (IQR 11.8) and 50.8 (IQR 15.4) for PROMIS-10-Physical, respectively. Discussion: This study provides one of the first overviews of distinct epilepsy, mental health, and quality-of-life metrics among SGM people. The low proportion of survey responses regarding sexual orientation and gender identity fields indicate the need for improved data collection methods in epilepsy clinics.

Identifiers

PMID39399565
PMCPMC11464218

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