Evidence map›Paper›PMID 39399562›Full record

ArticleNeurology. Clinical practice2025

Outcomes and Recurrence Rates Among Patients With Provoked and Cryptogenic Cerebral Venous Thrombosis: Analysis of the ACTION CVT.

Sami Al Kasab, Eyad Almallouhi, Liqi Shu, Kimberly P Kicielinski, Setareh Salehi Omran, David S Liebeskind, Adeel S Zubair, Maria C Vedovati, Maurizio Paciaroni, Kateryna Antonenko and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Cerebral venous thrombosis: Current management, recent advances and future directions.International journal of stroke : official journal of the International Stroke Society · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sami Al KasabDepartment of Neurology (SAK, EA); Department of Neurosurgery (SAK, EA, KPK), Medical University of South Carolina, Charleston, SC; Department of Neurology (LS, SY), Brown University, Providence, RI; Department of Neurology (SSO), University of Colorado School of Medicine, Aurora; Department of Neurology (DSL), University of California at Los Angeles; Department of Neurology (ASZ, AH), Yale University, New Haven, CT; Department of Medicine and Surgery (MCV, MP), University of Perugia, Italy; Department of Neurology (KA, MRH), University Hospital and University of Bern, Switzerland; Department of Neurology (NH), and Department of Psychiatry (NH), University of Massachusetts, Worcester, MA.ORCID https://orcid.org/0000-0001-8909-9761
Eyad AlmallouhiDepartment of Neurology (SAK, EA); Department of Neurosurgery (SAK, EA, KPK), Medical University of South Carolina, Charleston, SC; Department of Neurology (LS, SY), Brown University, Providence, RI; Department of Neurology (SSO), University of Colorado School of Medicine, Aurora; Department of Neurology (DSL), University of California at Los Angeles; Department of Neurology (ASZ, AH), Yale University, New Haven, CT; Department of Medicine and Surgery (MCV, MP), University of Perugia, Italy; Department of Neurology (KA, MRH), University Hospital and University of Bern, Switzerland; Department of Neurology (NH), and Department of Psychiatry (NH), University of Massachusetts, Worcester, MA.ORCID https://orcid.org/0000-0002-6873-7901
Liqi ShuDepartment of Neurology (SAK, EA); Department of Neurosurgery (SAK, EA, KPK), Medical University of South Carolina, Charleston, SC; Department of Neurology (LS, SY), Brown University, Providence, RI; Department of Neurology (SSO), University of Colorado School of Medicine, Aurora; Department of Neurology (DSL), University of California at Los Angeles; Department of Neurology (ASZ, AH), Yale University, New Haven, CT; Department of Medicine and Surgery (MCV, MP), University of Perugia, Italy; Department of Neurology (KA, MRH), University Hospital and University of Bern, Switzerland; Department of Neurology (NH), and Department of Psychiatry (NH), University of Massachusetts, Worcester, MA.ORCID https://orcid.org/0000-0002-9784-8475
Kimberly P KicielinskiDepartment of Neurology (SAK, EA); Department of Neurosurgery (SAK, EA, KPK), Medical University of South Carolina, Charleston, SC; Department of Neurology (LS, SY), Brown University, Providence, RI; Department of Neurology (SSO), University of Colorado School of Medicine, Aurora; Department of Neurology (DSL), University of California at Los Angeles; Department of Neurology (ASZ, AH), Yale University, New Haven, CT; Department of Medicine and Surgery (MCV, MP), University of Perugia, Italy; Department of Neurology (KA, MRH), University Hospital and University of Bern, Switzerland; Department of Neurology (NH), and Department of Psychiatry (NH), University of Massachusetts, Worcester, MA.ORCID https://orcid.org/0000-0003-0460-6280
Setareh Salehi OmranDepartment of Neurology (SAK, EA); Department of Neurosurgery (SAK, EA, KPK), Medical University of South Carolina, Charleston, SC; Department of Neurology (LS, SY), Brown University, Providence, RI; Department of Neurology (SSO), University of Colorado School of Medicine, Aurora; Department of Neurology (DSL), University of California at Los Angeles; Department of Neurology (ASZ, AH), Yale University, New Haven, CT; Department of Medicine and Surgery (MCV, MP), University of Perugia, Italy; Department of Neurology (KA, MRH), University Hospital and University of Bern, Switzerland; Department of Neurology (NH), and Department of Psychiatry (NH), University of Massachusetts, Worcester, MA.ORCID https://orcid.org/0000-0002-3184-5327
David S LiebeskindDepartment of Neurology (SAK, EA); Department of Neurosurgery (SAK, EA, KPK), Medical University of South Carolina, Charleston, SC; Department of Neurology (LS, SY), Brown University, Providence, RI; Department of Neurology (SSO), University of Colorado School of Medicine, Aurora; Department of Neurology (DSL), University of California at Los Angeles; Department of Neurology (ASZ, AH), Yale University, New Haven, CT; Department of Medicine and Surgery (MCV, MP), University of Perugia, Italy; Department of Neurology (KA, MRH), University Hospital and University of Bern, Switzerland; Department of Neurology (NH), and Department of Psychiatry (NH), University of Massachusetts, Worcester, MA.ORCID https://orcid.org/0000-0002-5109-8736
Adeel S ZubairDepartment of Neurology (SAK, EA); Department of Neurosurgery (SAK, EA, KPK), Medical University of South Carolina, Charleston, SC; Department of Neurology (LS, SY), Brown University, Providence, RI; Department of Neurology (SSO), University of Colorado School of Medicine, Aurora; Department of Neurology (DSL), University of California at Los Angeles; Department of Neurology (ASZ, AH), Yale University, New Haven, CT; Department of Medicine and Surgery (MCV, MP), University of Perugia, Italy; Department of Neurology (KA, MRH), University Hospital and University of Bern, Switzerland; Department of Neurology (NH), and Department of Psychiatry (NH), University of Massachusetts, Worcester, MA.ORCID https://orcid.org/0000-0002-9809-7888
Maria C VedovatiDepartment of Neurology (SAK, EA); Department of Neurosurgery (SAK, EA, KPK), Medical University of South Carolina, Charleston, SC; Department of Neurology (LS, SY), Brown University, Providence, RI; Department of Neurology (SSO), University of Colorado School of Medicine, Aurora; Department of Neurology (DSL), University of California at Los Angeles; Department of Neurology (ASZ, AH), Yale University, New Haven, CT; Department of Medicine and Surgery (MCV, MP), University of Perugia, Italy; Department of Neurology (KA, MRH), University Hospital and University of Bern, Switzerland; Department of Neurology (NH), and Department of Psychiatry (NH), University of Massachusetts, Worcester, MA.ORCID https://orcid.org/0000-0002-2268-9983
Maurizio PaciaroniDepartment of Neurology (SAK, EA); Department of Neurosurgery (SAK, EA, KPK), Medical University of South Carolina, Charleston, SC; Department of Neurology (LS, SY), Brown University, Providence, RI; Department of Neurology (SSO), University of Colorado School of Medicine, Aurora; Department of Neurology (DSL), University of California at Los Angeles; Department of Neurology (ASZ, AH), Yale University, New Haven, CT; Department of Medicine and Surgery (MCV, MP), University of Perugia, Italy; Department of Neurology (KA, MRH), University Hospital and University of Bern, Switzerland; Department of Neurology (NH), and Department of Psychiatry (NH), University of Massachusetts, Worcester, MA.ORCID https://orcid.org/0000-0002-5483-8795
Kateryna AntonenkoDepartment of Neurology (SAK, EA); Department of Neurosurgery (SAK, EA, KPK), Medical University of South Carolina, Charleston, SC; Department of Neurology (LS, SY), Brown University, Providence, RI; Department of Neurology (SSO), University of Colorado School of Medicine, Aurora; Department of Neurology (DSL), University of California at Los Angeles; Department of Neurology (ASZ, AH), Yale University, New Haven, CT; Department of Medicine and Surgery (MCV, MP), University of Perugia, Italy; Department of Neurology (KA, MRH), University Hospital and University of Bern, Switzerland; Department of Neurology (NH), and Department of Psychiatry (NH), University of Massachusetts, Worcester, MA.ORCID https://orcid.org/0000-0002-1936-5451
Mirjam R HeldnerDepartment of Neurology (SAK, EA); Department of Neurosurgery (SAK, EA, KPK), Medical University of South Carolina, Charleston, SC; Department of Neurology (LS, SY), Brown University, Providence, RI; Department of Neurology (SSO), University of Colorado School of Medicine, Aurora; Department of Neurology (DSL), University of California at Los Angeles; Department of Neurology (ASZ, AH), Yale University, New Haven, CT; Department of Medicine and Surgery (MCV, MP), University of Perugia, Italy; Department of Neurology (KA, MRH), University Hospital and University of Bern, Switzerland; Department of Neurology (NH), and Department of Psychiatry (NH), University of Massachusetts, Worcester, MA.ORCID https://orcid.org/0000-0002-3594-2159
Adam de HavenonDepartment of Neurology (SAK, EA); Department of Neurosurgery (SAK, EA, KPK), Medical University of South Carolina, Charleston, SC; Department of Neurology (LS, SY), Brown University, Providence, RI; Department of Neurology (SSO), University of Colorado School of Medicine, Aurora; Department of Neurology (DSL), University of California at Los Angeles; Department of Neurology (ASZ, AH), Yale University, New Haven, CT; Department of Medicine and Surgery (MCV, MP), University of Perugia, Italy; Department of Neurology (KA, MRH), University Hospital and University of Bern, Switzerland; Department of Neurology (NH), and Department of Psychiatry (NH), University of Massachusetts, Worcester, MA.ORCID https://orcid.org/0000-0001-8178-8597
Nils HenningerDepartment of Neurology (SAK, EA); Department of Neurosurgery (SAK, EA, KPK), Medical University of South Carolina, Charleston, SC; Department of Neurology (LS, SY), Brown University, Providence, RI; Department of Neurology (SSO), University of Colorado School of Medicine, Aurora; Department of Neurology (DSL), University of California at Los Angeles; Department of Neurology (ASZ, AH), Yale University, New Haven, CT; Department of Medicine and Surgery (MCV, MP), University of Perugia, Italy; Department of Neurology (KA, MRH), University Hospital and University of Bern, Switzerland; Department of Neurology (NH), and Department of Psychiatry (NH), University of Massachusetts, Worcester, MA.ORCID https://orcid.org/0000-0002-3883-5623
Shadi YaghiDepartment of Neurology (SAK, EA); Department of Neurosurgery (SAK, EA, KPK), Medical University of South Carolina, Charleston, SC; Department of Neurology (LS, SY), Brown University, Providence, RI; Department of Neurology (SSO), University of Colorado School of Medicine, Aurora; Department of Neurology (DSL), University of California at Los Angeles; Department of Neurology (ASZ, AH), Yale University, New Haven, CT; Department of Medicine and Surgery (MCV, MP), University of Perugia, Italy; Department of Neurology (KA, MRH), University Hospital and University of Bern, Switzerland; Department of Neurology (NH), and Department of Psychiatry (NH), University of Massachusetts, Worcester, MA.ORCID https://orcid.org/0000-0003-0031-1004

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Background and Objectives: Cerebral venous thrombosis (CVT) is a rare cause of stroke. While the standard treatment is anticoagulation, the type and duration of anticoagulation depends on the underlying etiology. This study aims to identify prevalence, risk factors, and recurrent venous thromboembolism (VTE) rates among patients with idiopathic (cryptogenic) CVT and CVT provoked by transient (peripartum, hormonal treatment, infection, trauma) and persistent (cancer, thrombophilia) factors. Methods: We used the ACTION-CVT retrospective database which included consecutive patients who were treated for CVT in 27 stroke centers in the United States, Europe, and New Zealand from January 2015 to December 2020. We compared baseline characteristics and outcomes of patients with cryptogenic, transient provoked (TP) and those with persistent provoked (PP) CVT. Baseline characteristics was compared between the groups using χ Results: Among 1,025 included participants with CVT, 510 (49.8%) had no identified risk factor (cryptogenic), 363 (35.4%) had at least one transient provoking factor, and 152 (14.8%) had a persistent provoking factor. Patients with TP CVT were younger ( Discussion: In this multicenter study, we found that outcomes of CVT differed depending on the underlying etiology. The risk of recurrent VTE in the PP and cryptogenic CVTs may be influenced by sex.

Identifiers

PMID39399562
PMCPMC11464219

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