Evidence map›Paper›PMID 39399271›Full record

ArticleJAMIA open2024

Barriers and facilitators of the use of clinical informatics resources to facilitate pharmacogenomic implementation in resource-limited settings.

Jade Bosic-Reiniger, James L Martin, Karen E Brown, Heather D Anderson, Hayley Blackburn, David P Kao, Katy E Trinkley, Erica L Woodahl, Christina L Aquilante

Abstract read
In one paragraph

Article in JAMIA open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jade Bosic-ReinigerL.S. Skaggs Institute for Health Innovation, University of Montana, Missoula, MT 59812, United States.
James L MartinDepartment of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO 80045, United States.
Karen E BrownL.S. Skaggs Institute for Health Innovation, University of Montana, Missoula, MT 59812, United States.
Heather D AndersonColorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States.
Hayley BlackburnL.S. Skaggs Institute for Health Innovation, University of Montana, Missoula, MT 59812, United States.
David P KaoColorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States.
Katy E TrinkleyDepartment of Family Medicine, University of Colorado School of Medicine, Aurora, CO 80045, United States.ORCID https://orcid.org/0000-0003-2041-7404
Erica L WoodahlL.S. Skaggs Institute for Health Innovation, University of Montana, Missoula, MT 59812, United States.
Christina L AquilanteDepartment of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO 80045, United States.

Funding

Personalizing Clinical Decision Support for Heart Failure Treatment to Clinicians' NeedsK23HL161352 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Katy E Trinkley · 2022 to 2026
$869k
NHLBI NIH HHS K23 HL161352
6 · The paper itself

Abstract

Objective: Understand perceived barriers to and facilitators of using clinical informatics applications for pharmacogenomic (PGx) implementation in resource-limited settings. Materials and Methods: We conducted a qualitative research study using a semi-structured interview guide informed by the Consolidated Framework for Implementation Research (CFIR). Interview questions assessed CFIR contextual determinants related to: electronic health record (EHR) infrastructure; clinical informatics personnel and resources; EHR integration of PGx test results; PGx clinical decision support (CDS) tools; institutional resources; and partner receptivity. Transcripts were coded and analyzed to identify themes. Results: We interviewed 24 clinical informaticists and executive leaders working in rural or underserved health care settings in Montana ( Discussion and Conclusion: Our results provide insight into the clinical informatics infrastructure in resource-limited settings and identify unique considerations for clinical informatics-facilitated PGx implementation. Future efforts in these settings should consider innovative partnerships and strategies to leverage facilitators and minimize barriers associated with integrating PGx CDS applications.

Indexed as

clinical informaticsimplementationpharmacogeneticspharmacogenomicsruralunderserved populations

Identifiers

PMID39399271
PMCPMC11471000

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.