Evidence map›Paper›PMID 39399223›Full record

ArticleNeurobiology of pain (Cambridge, Mass.)

Novel therapies for cancer-induced bone pain.

Rayan Haroun, Samuel J Gossage, Federico Iseppon, Alexander Fudge, Sara Caxaria, Manuel Arcangeletti, Charlotte Leese, Bazbek Davletov, James J Cox, Shafaq Sikandar and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of pain (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rayan HarounMolecular Nociception Group, Wolfson Institute for Biomedical Research (WIBR), University College London (UCL), London WC1E 6BT, United Kingdom.
Samuel J GossageMolecular Nociception Group, Wolfson Institute for Biomedical Research (WIBR), University College London (UCL), London WC1E 6BT, United Kingdom.
Federico IsepponMolecular Nociception Group, Wolfson Institute for Biomedical Research (WIBR), University College London (UCL), London WC1E 6BT, United Kingdom.
Alexander FudgeMolecular Nociception Group, Wolfson Institute for Biomedical Research (WIBR), University College London (UCL), London WC1E 6BT, United Kingdom.
Sara CaxariaWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Manuel ArcangelettiMolecular Nociception Group, Wolfson Institute for Biomedical Research (WIBR), University College London (UCL), London WC1E 6BT, United Kingdom.
Charlotte LeeseDepartment of Biomedical Science, University of Sheffield, South Yorkshire S10 2TN, United Kingdom.
Bazbek DavletovDepartment of Biomedical Science, University of Sheffield, South Yorkshire S10 2TN, United Kingdom.
James J CoxMolecular Nociception Group, Wolfson Institute for Biomedical Research (WIBR), University College London (UCL), London WC1E 6BT, United Kingdom.
Shafaq SikandarWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Fraser WelshAstraZeneca BioPharmaceuticals R&D, Neuroscience, Discovery Centre, Biomedical campus, 1 Francis Crick Ave, Cambridge CB2 0AA, United Kingdom.
Iain P ChessellAstraZeneca BioPharmaceuticals R&D, Neuroscience, Discovery Centre, Biomedical campus, 1 Francis Crick Ave, Cambridge CB2 0AA, United Kingdom.
John N WoodMolecular Nociception Group, Wolfson Institute for Biomedical Research (WIBR), University College London (UCL), London WC1E 6BT, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer pain is a growing problem, especially with the substantial increase in cancer survival. Reports indicate that bone metastasis, whose primary symptom is bone pain, occurs in 65-75% of patients with advanced breast or prostate cancer. We optimized a preclinical

Indexed as

Acid-sensing ion channelsCancer-induced bone painDorsal root gangliaModified botulinum compoundsNerve growth factorTumor necrosis factor alphaVoltage-gated sodium channels

Identifiers

PMID39399223
PMCPMC11470602

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.