Evidence map›Paper›PMID 39399045›Full record

ArticlemedRxiv : the preprint server for health sciences2024

The JAK inhibitor, Tofacitinib, Corrects the Overexpression of CEACAM6 and Limits Susceptibility to AIEC Caused by Reduced Activity of the IBD Associated Gene,

Pritha Chatterjee, Vinicius Canale, Stephanie J King, Ali Shawki, Hillmin Lei, Michael Haddad, Casey M Gries, Dermot P B McGovern, James Borneman, Declan F McCole

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pritha ChatterjeeDivision of Biomedical Sciences, University of California, Riverside, Riverside, California.
Vinicius CanaleDivision of Biomedical Sciences, University of California, Riverside, Riverside, California.
Stephanie J KingDivision of Biomedical Sciences, University of California, Riverside, Riverside, California.
Ali ShawkiDivision of Biomedical Sciences, University of California, Riverside, Riverside, California.
Hillmin LeiDivision of Biomedical Sciences, University of California, Riverside, Riverside, California.
Michael HaddadDepartment of Biology, University of California, Riverside, Riverside, California.
Casey M GriesDivision of Biomedical Sciences, University of California, Riverside, Riverside, California.
Dermot P B McGovernDepartment of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, California.
James BornemanDepartment of Microbiology and Plant Pathology, University of California, Riverside, California.
Declan F McColeDivision of Biomedical Sciences, University of California, Riverside, Riverside, California.

Funding

San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2019 to 2026
$10.8M
A NOVEL ROLE FOR PTPN2 IN INTESTINAL EPITHELIAL BARRIER REGULATIONR01DK091281 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Declan McCole · 2012 to 2026
$5.5M
Tyrosine Phosphatase Regulation of Mucosal Macrophage-Epithelial Cell Cross-talkR01AI153314 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI MCCOLE, DECLAN · 2020 to 2024
$2.5M
Inflammatory Bowel Disease Susceptibility Gene Regulation of AnemiaR21AI152017 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI MCCOLE, DECLAN · 2021 to 2022
$428k
NIAID NIH HHS R01 AI153314NIAID NIH HHS R21 AI152017NIDDK NIH HHS P30 DK120515NIDDK NIH HHS R01 DK091281
6 · The paper itself

Abstract

Background and Aims: A cohort of patients with inflammatory bowel disease (IBD) exhibit expansion of the gut pathobiont, adherent-invasive Methods: Biopsies from IBD patients heterozygous (CT) or homozygous (CC) for the Results: CEACAM6 expression was elevated (colon and ileum) in IBD patients carrying the Conclusion: Our findings highlight a crucial role for

Identifiers

PMID39399045
PMCPMC11469354

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.