Evidence map›Paper›PMID 39399044›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Lipid Trajectories Improve Risk Models for Alzheimer's Disease and Mild Cognitive Impairment.

Bruce A Chase, Roberta Frigerio, Chad J Yucus, Smita Patel, Demetrius Maraganore, Alan R Sanders, Jubao Duan, Katerina Markopoulou

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Bruce A ChaseInformation Technology, Endeavor Health, Skokie, IL USA.ORCID 0000-0001-5491-7242
Roberta FrigerioPritzker School of Medicine, Chicago, USA.
Chad J YucusDepartment of Neurology, Endeavor Health, Evanston, IL USA.
Smita PatelDepartment of Neurology, Endeavor Health, Evanston, IL USA.
Demetrius MaraganoreDepartment of Neurology, Tulane University School of Medicine, New Orleans, LA USA.
Alan R SandersCenter for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL USA.
Jubao DuanCenter for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL USA.
Katerina MarkopoulouDepartment of Neurology, Endeavor Health, Evanston, IL USA.

Funding

Modeling Alzheimer's disease genetic variants in hiPSCR01AG063175 · NIA · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI DUAN, JUBAO, THINAKARAN, GOPAL · 2019 to 2023
$3.7M
Neuronal Vulnerability to Lipid Droplets and Cholesterol in Alzheimer's DiseaseR01AG081374 · NIA · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI Jubao Duan · 2023 to 2026
$2.7M
Quality Improvement and Practice Based Research in Neurology Using the EMRR01HS024057 · AHRQ · UNIVERSITY OF FLORIDA · PI MARAGANORE, DEMETRIUS MICHAEL · 2015 to 2019
$1.1M
AHRQ HHS R01 HS024057NIA NIH HHS R01 AG063175NIA NIH HHS R01 AG081374
6 · The paper itself

Abstract

To assess the relationship between lipids and cognitive dysfunction, we retrospectively analyzed blood-lipid levels in clinically well-characterized individuals with stable mild cognitive impairment (MCI) or Alzheimer's disease (AD) over the decade prior to first cognitive symptoms. In this case/control cohort study, AD and MCI cases were diagnosed using DSM-IV criteria; MCI cases had not progressed to dementia for ≥5 years; and controls were propensity matched to cases at age of symptom onset (MCI: 116 cases, 435 controls; AD: 215 cases, 483 controls). Participants were grouped based on longitudinal trajectories and quintile of variability independent of the mean (VIM) for total cholesterol, HDL-C, LDL-C, non-HDL-C and ln(triglycerides). Models for the risk of cognitive dysfunction evaluated trajectory and VIM groups,

Indexed as

Alzheimer’s diseaseAPOEcholesterolgroup-based trajectory analysisHDL-CLDLlipidspolygenic risk scoretriglyceridesvariability independent of the mean

Identifiers

PMID39399044
PMCPMC11469357

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.