Evidence map›Paper›PMID 39399043›Full record

ArticlemedRxiv : the preprint server for health sciences2024

PTSD-related differences in resting-state functional connectivity and associations with sex hormones.

Natalie C Noble, Mohammad S E Sendi, Julia B Merker, Samantha R Linton, Theresa K Webber, Amit Etkin, Wei Wu, Kerry J Ressler, Antonia V Seligowski

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Natalie C NobleDepartment of Psychological Science, University of Vermont, Burlington, VT, USA.
Mohammad S E SendiDeparment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Julia B MerkerDepartment of Psychological & Brain Sciences, University of Delaware, Newark, DE, USA.
Samantha R LintonDeparment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Theresa K WebberDivision of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA.
Amit EtkinAlto Neuroscience, Palo Alto, CA, USA.
Wei WuAlto Neuroscience, Palo Alto, CA, USA.
Kerry J ResslerDeparment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Antonia V SeligowskiDeparment of Psychiatry, Harvard Medical School, Boston, MA, USA.

Funding

Training to Enhance Alignment of Psychiatry and NeuroscienceT32MH125786 · NIMH · MCLEAN HOSPITAL · PI William A. Carlezon, KERRY J. RESSLER · 2021 to 2026
$2.0M
A Multi-Modal Investigation of Neurophysiological Deficits in PTSDK23MH125920 · NIMH · MCLEAN HOSPITAL · PI SELIGOWSKI, ANTONIA · 2021 to 2025
$870k
NIMH NIH HHS K23 MH125920NIMH NIH HHS T32 MH125786
6 · The paper itself

Abstract

Background: Posttraumatic stress disorder (PTSD) is a debilitating condition that disproportionately impacts individuals who are female. Prior research indicates that males with PTSD exhibit hypoconnectivity of frontal brain regions measured with resting electroencephalography (EEG). The present study examined functional connectivity among females with PTSD and trauma-exposed controls, as well as the impact of sex hormones. Methods: Participants included 61 females ( Results: Compared to controls, the PTSD group displayed hyperconnectivity between visual brain regions and the rest of the cerebral cortex ( Conclusions: Results are consistent with prior research indicating that PTSD is associated with altered connectivity in visual brain regions, which may reflect disrupted visual processing related to reexperiencing symptoms (e.g., intrusive memories). Our findings provide additional support for the relevance of the theta frequency range in PTSD given its role in fear learning and regulation processes.

Identifiers

PMID39399043
PMCPMC11469513

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.