Evidence map›Paper›PMID 39399037›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Elevated blood glucose levels are associated with the progression of brain hypometabolism, and HDL-C and

Aravind Lathika Rajendrakumar, Svetlana Ukraintseva, Olivia Bagley, Matt Duan, Anatoliy I Yashin, Konstantin G Arbeev, Alzheimer’s Disease Neuroimaging Initiative

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aravind Lathika RajendrakumarBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, 27708-0408, USA.ORCID 0000-0002-4286-7265
Svetlana UkraintsevaBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, 27708-0408, USA.
Olivia BagleyBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, 27708-0408, USA.
Matt DuanBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, 27708-0408, USA.
Anatoliy I YashinBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, 27708-0408, USA.
Konstantin G ArbeevBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, 27708-0408, USA.ORCID 0000-0002-4195-7832
Alzheimer’s Disease Neuroimaging Initiative

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Understanding Alzheimer's Disease in the Context of the AgingR01AG062623 · NIA · DUKE UNIVERSITY · PI OUKRAINTSEVA, SVETLANA V. · 2019 to 2023
$3.6M
Genetics of aging, health and longevity: focus on regulatory mechanisms and functional variants connecting aging and Alzheimer's diseaseR01AG070487 · NIA · DUKE UNIVERSITY · PI KULMINSKI, ALEXANDER M, OUKRAINTSEVA, SVETLANA V. · 2020 to 2023
$2.0M
NIA NIH HHS R01 AG062623NIA NIH HHS R01 AG070487NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

Background: Brain glucose hypometabolism has consistently been found in neurodegenerative disorders, including Alzheimer's disease (AD). High blood glucose and HDL cholesterol (HDL-C) levels have also been linked to neurodegeneration and AD. However, there is limited understanding of the relationships between dementia-related risk factors in the brain and blood. Methods: A linear mixed model was used to examine the relationship between blood glucose and HDL-C levels and the progression of brain hypometabolism, adjusting for Results: There were 336 individuals (781 observations), of whom 22.62% had AD. The majority were male (63.98%) and of white race, and 48.51% were carriers of Conclusion: High plasma glucose levels facilitated the progression of brain hypometabolism. The effect was more prominent in the

Indexed as

Alzheimer’s diseaseAPOE4Blood glucoseBrain hypometabolismHDL cholesterolHypometabolic Convergence Index

Identifiers

PMID39399037
PMCPMC11469353

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.