Evidence map›Paper›PMID 39399016›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Arsenic exposure is associated with elevated sweat chloride concentration and airflow obstruction among adults in Bangladesh: a cross sectional study.

Mi-Sun S Lee, Crystal M North, Irada Choudhuri, Subrata K Biswas, Abby F Fleisch, Afifah Farooque, Diane Bao, Sakila Afroz, Sadia Mow, Nazmul Husain and 9 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Mi-Sun S LeeDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA USA.ORCID 0000-0002-3106-220X
Crystal M NorthDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA USA.
Irada ChoudhuriDepartment of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Subrata K BiswasDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, CT, USA.
Abby F FleischCenter for Interdisciplinary Population Health Research, MaineHealth, Portland, ME USA.
Afifah FarooqueDepartment of Neurology, Boston Children's Hospital, Boston, MA USA.
Diane BaoDepartment of Neurology, Boston Children's Hospital, Boston, MA USA.ORCID 0000-0003-2452-7678
Sakila AfrozDhaka Community Hospital Trust, Dhaka Bangladesh.
Sadia MowDhaka Community Hospital Trust, Dhaka Bangladesh.
Nazmul HusainDhaka Community Hospital Trust, Dhaka Bangladesh.
Fuadul IslamDhaka Community Hospital Trust, Dhaka Bangladesh.
Md Golam MostafaDhaka Community Hospital Trust, Dhaka Bangladesh.
Partha Pratim BiswasDepartment of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
David S LudwigNew Balance Obesity Prevention Center, Boston Children's Hospital, Boston, MA USA.
Subba R DigumarthyThoracic Imaging and Intervention Division, Massachusetts General Hospital, Boston, MA USA.
Christopher HugConsultant, Brookline, MA, USA.
Quazi QuamruzzamanDhaka Community Hospital Trust, Dhaka Bangladesh.
David C ChristianiDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA USA.ORCID 0000-0002-0301-0242
Maitreyi MazumdarDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA USA.ORCID 0000-0003-0380-2407

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Marc G Weisskopf · 1985 to 2026
$44.6M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4M
Arsenic related cystic fibrosisR01ES027825 · NIEHS · BOSTON CHILDREN'S HOSPITAL · PI MAZUMDAR, MAITREYI · 2018 to 2022
$2.1M
Arsenic Exposure and Skin Diseases in BangladeshR01ES011622 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI CHRISTIANI, DAVID C · 2002 to 2005
$2.0M
The influence of air pollution on lung health among people living with HIV.K23HL154863 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NORTH, CRYSTAL · 2020 to 2024
$1.1M
NHLBI NIH HHS K23 HL154863NICHD NIH HHS P50 HD105351NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES011622NIEHS NIH HHS R01 ES027825
6 · The paper itself

Abstract

Arsenic is associated with lung disease and experimental models suggest that arsenic-induced degradation of the chloride channel CFTR (cystic fibrosis transmembrane conductance regulator) is a mechanism of arsenic toxicity. We examined associations between arsenic exposure, sweat chloride concentration (measure of CFTR function), and pulmonary function among 285 adults in Bangladesh. Participants with sweat chloride ≥ 60 mmol/L had higher arsenic exposures than those with sweat chloride < 60 mmol/L (water: median 77.5 μg/L versus 34.0 μg/L,

Identifiers

PMID39399016
PMCPMC11469388

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.