Evidence map›Paper›PMID 39398998›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Neuropsychiatric Symptoms Cluster and Fluctuate Over Time in Behavioral Variant Frontotemporal Dementia.

Christopher B Morrow, Vidyulata Kamath, Bradford C Dickerson, Mark Eldaief, Neguine Rezaii, Bonnie Wong, Scott McGinnis, Ryan Darby, Adam M Staffaroni, Maria I Lapid and 15 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors.

Christopher B MorrowDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.
Vidyulata KamathDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.
Bradford C DickersonDepartment of Neurology, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA.
Mark EldaiefDepartment of Neurology, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA.
Neguine RezaiiDepartment of Neurology, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA.ORCID 0000-0002-5958-3445
Bonnie WongDepartment of Neurology, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA.
Scott McGinnisDepartment of Neurology, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA.
Ryan DarbyDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN.
Adam M StaffaroniDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA.
Maria I LapidDepartment of Psychiatry and Neurology, Mayo Clinic, Rochester, MN.
Belen PascualDepartment of Neurology, Houston Methodist Research Institute, Houston, TX.
Julio C RojasDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA.
Joseph C MasdeuDepartment of Neurology, Houston Methodist Research Institute, Houston, TX.
Kyrana TsapkiniDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.
Edward D HueyAlpert Medical School of Brown University, Department of Psychiatry and Human Behavior Providence, RI.
Daniel W FisherDepartment of Neurology, University of Washington School of Medicine, Seattle, WA.
Alexander PantelyatDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0002-6427-7485
Akshata BalajiDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.
Eric SahDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.
Irene LitvanDepartment of Neurosciences, UC San Diego, La Jolla, CA.
Katya RascovskyDepartment of Neurology and Penn Frontotemporal Degeneration Center University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
Nupur GhoshalDepartment of Neurology, Washington University School of Medicine, St. Louis, MO.
Kimiko Domoto-ReillyDepartment of Neurology, University of Washington School of Medicine, Seattle, WA.
John KornakDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA.
Chiadi U OnyikeDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.

Funding

Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI KEJAL KANTARCI · 2019 to 2026
$120.9M
The Four Repeat Tauopathy Neuroimaging InitiativeR01AG038791 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2010 to 2020
$18.1M
Dementia with Lewy Bodies Consortium - Supplement for ASL sequenceU01NS100610 · NINDS · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI DOUGLAS R GALASKO, JAMES Bruce LEVERENZ · 2016 to 2026
$15.6M
Institutional Career Development CoreKL2TR003099 · NCATS · JOHNS HOPKINS UNIVERSITY · PI GEBO, KELLY A · 2019 to 2023
$7.9M
Neurobehavior, Neuropathology, and Risk Factors in Alzheimer's DiseaseT32AG052354 · NIA · UNIVERSITY OF WASHINGTON · PI Brian C. Kraemer, ELAINE R. PESKIND · 2016 to 2026
$6.7M
Phase II clinical trial of transcranial direct current stimulation in the treatment of primary progressive aphasiaR01AG075111 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Roy H Hamilton, Kyrana Tsapkini · 2022 to 2026
$6.7M
BIOMARKER DISCOVERY AND VALIDATION IN PSPU01NS102035 · NINDS · JOHNS HOPKINS UNIVERSITY · PI PANTELYAT, ALEXANDER Y. · 2018 to 2022
$4.5M
Targeting language-specific and executive-control networks with transcranial direct current stimulation in aphasic ADR01AG075404 · NIA · JOHNS HOPKINS UNIVERSITY · PI Kyrana Tsapkini · 2022 to 2026
$4.0M
Advanced MR Imaging of Olfactory Impairment in Prodromal Alzheimer's DiseaseR01AG064093 · NIA · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI BAKKER, ARNOLD, HUA, JUN · 2020 to 2024
$3.9M
Transcranial direct current stimulation in typical and atypical Alzheimer's diseaseR01AG068881 · NIA · JOHNS HOPKINS UNIVERSITY · PI TSAPKINI, KYRANA · 2020 to 2024
$3.8M
Imaging small blood and lymphatic vessel abnormalities of the olfactory system in schizophreniaR01NS108452 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI HUA, JUN, KAMATH, VIDYULATA · 2018 to 2022
$3.2M
Training in Research to Assure Neuroscience Scholars Cultivate Expertise in Notable Disparities Science (TRANSCENDS)R25NS098999 · NINDS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI BRUCE OVBIAGELE · 2017 to 2026
$2.5M
NCATS NIH HHS KL2 TR003099NIA NIH HHS K23 AG059888NIA NIH HHS K23 AG059891NIA NIH HHS K23 AG088248NIA NIH HHS L30 AG083912NIA NIH HHS R01 AG038791NIA NIH HHS R01 AG064093NIA NIH HHS R01 AG068881NIA NIH HHS R01 AG075111NIA NIH HHS R01 AG075404NIA NIH HHS T32 AG052354NIA NIH HHS U19 AG063911NINDS NIH HHS R01 NS108452NINDS NIH HHS R21 NS114764NINDS NIH HHS R25 NS098999NINDS NIH HHS U01 NS100610NINDS NIH HHS U01 NS102035
6 · The paper itself

Abstract

Objectives: Cognitive and behavioral phenomena define behavioral variant frontotemporal dementia (bvFTD), but neuropsychiatric symptoms (NPS) outside the core criteria are common throughout the illness. Identifying how NPS cluster in bvFTD may clarify the underlying neurobiology of bvFTD-related NPS and guide development of therapies. Methodology: Participants (N=354) with sporadic and genetic bvFTD were enrolled in the ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration Consortium. Dementia stage was defined as early (CDR Results: NPS were highly prevalent (≥ 90%) in early and late bvFTD. Four NPS clusters were identified based on magnitude of factor loadings: affective, disinhibited, compulsive, and psychosis. Neuropsychiatric symptoms fluctuated across visits. In the affective cluster, depression and anxiety showed the least visit-to-visit stability. In the disinhibited cluster, elation showed the least stability. Symptoms in the psychosis and compulsive clusters (hallucinations, delusions, obsessions/compulsions, and hyperorality) were largely stable, persisting from visit-to-visit in more than 50% of cases. Conclusion: NPS in bvFTD are frequent and cluster into four discrete groups in bvFTD. These clusters may result from specific neural network disruptions that could serve as targets for future interventions. The fluctuating nature of NPS in bvFTD suggests that they are not reliable markers of disease progression or stage.

Indexed as

Behavioral And Psychological Symptoms of DementiaFrontotemporal DementiaNeuropsychiatryPsychiatric Symptoms

Identifiers

PMID39398998
PMCPMC11469469

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.