Evidence map›Paper›PMID 39398945›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)

Resistance and resilience to tau pathology in Alzheimer's disease: Effects of age, sex, and

Yury Loika, Stephanie Webster, Elena Loiko, Alexander M Kulminski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yury LoikaBiodemography of Aging Research Unit Social Science Research Institute Duke University Durham North Carolina USA.ORCID https://orcid.org/0000-0001-6730-7320
Stephanie WebsterBiodemography of Aging Research Unit Social Science Research Institute Duke University Durham North Carolina USA.
Elena LoikoBiodemography of Aging Research Unit Social Science Research Institute Duke University Durham North Carolina USA.
Alexander M KulminskiBiodemography of Aging Research Unit Social Science Research Institute Duke University Durham North Carolina USA.

Funding

Relationships among Genetic Regulators of Aging Health and LifespanP01AG043352 · NIA · DUKE UNIVERSITY · PI YASHIN, ANATOLIY I · 2014 to 2018
$8.7M
ApoE2 and protective molecular signatures in Alzheimer's disease and agingR01AG061853 · NIA · DUKE UNIVERSITY · PI KULMINSKI, ALEXANDER M · 2018 to 2022
$3.9M
Personalized genetic profiles of risk and resilience in Alzheimer's and vascular diseasesR01AG065477 · NIA · DUKE UNIVERSITY · PI KULMINSKI, ALEXANDER M · 2020 to 2024
$3.8M
Dissecting genetic and non-genetic heterogeneity in predisposition to Alzheimer's disease and vascular traits in pleiotropic contextR01AG070488 · NIA · DUKE UNIVERSITY · PI KULMINSKI, ALEXANDER M, OUKRAINTSEVA, SVETLANA V. · 2020 to 2024
$2.8M
Molecular signatures of health and life span disparities between whites and African-Americans in the APOE regionR01AG047310 · NIA · DUKE UNIVERSITY · PI KULMINSKI, ALEXANDER M · 2015 to 2019
$2.5M
NIA NIH HHS P01 AG043352NIA NIH HHS R01 AG047310NIA NIH HHS R01 AG061853NIA NIH HHS R01 AG065477NIA NIH HHS R01 AG070488
6 · The paper itself

Abstract

introductionNeurofibrillary tangles (NFTs), a hallmark of tau pathology in Alzheimer's disease (AD), accumulate in the aging brain. However, some individuals remain cognitively intact despite high Braak (III-VI) stages, which characterize NFTs' accumulation.

methodsWe studied resistance and resilience to tau pathology by assessing Braak stages based on apolipoprotein E (

resultsResistance, characterized by low (0-II) Braak stages, was observed in men and women younger than 85 years of age. Resilience, indicated by high (III-VI) Braak stages, increased significantly with age in both men and women for each DISCUSSION: The identification of factors underlying resistance and resilience against AD-related pathologies is essential for promoting cognitively healthy aging. Highlights: We investigated cognitive resistance and resilience to tau pathology in Alzheimer's disease (AD).This study included individuals who were not diagnosed with AD.Braak stages 0-II and III-VI were considered as a measure of resistance and resilience, respectively.Resistance was stronger at ages younger than 85 years in non-carriers of the apolipoprotein E (

Indexed as

agingAlzheimer's diseaseAPOE alleleBraak stagescognitive healthneurofibrillary tangles (NFTs)resilienceresistancesextau pathology

Identifiers

PMID39398945
PMCPMC11470232

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.