Evidence map›Paper›PMID 39398551›Full record

ArticleAmerican journal of translational research2024

Combination of melatonin-delivered endothelial progenitor cells with S-nitroso-N-acetyl-DL-penicillamine for improving critical limb ischemia in the rat.

Jui-Ning Yeh, Hon-Kan Yip, Pei-Lin Shao, John Y Chiang, Shun-Cheng Wu, Pei-Hsun Sung, Jiunn-Jye Sheu, Jun Guo

Abstract read
In one paragraph

Article in American journal of translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jui-Ning YehDepartment of Cardiology, The First Affiliated Hospital, Jinan University Guangzhou 510630, Guangdong, China.
Hon-Kan YipDivision of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine Kaohsiung 83301, Taiwan.
Pei-Lin ShaoDepartment of Nursing, Asia University Taichung 41354, Taiwan.
John Y ChiangDepartment of Computer Science and Engineering, National Sun Yat-Sen University Kaohsiung 80424, Taiwan.
Shun-Cheng WuRegenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University Kaohsiung 80787, Taiwan.
Pei-Hsun SungDivision of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine Kaohsiung 83301, Taiwan.
Jiunn-Jye SheuDivision of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine Kaohsiung 83301, Taiwan.
Jun GuoDepartment of Cardiology, The First Affiliated Hospital, Jinan University Guangzhou 510630, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study tested whether combined shock wave (SW)-facilitated melatonin (Mel) delivered into endothelial progenitor cells (EPCs) (EPC

methodsSD rats (n = 50) were equally categorized into group 1 (sham-control), group 2 (CLI), group 3 (CLI + SNAP), group 4 (CLI + EPC

resultsAn in vitro study showed that at time points of 24/48/72 h, the cell viability/protein expression of endothelial nitric oxide synthase (eNOS)/and cellular expression of nitric oxide (NO) were highest in EPCs, lowest in EPCs + menadione, and much higher in EPC

conclusionsCombined EPC

Indexed as

angiogenesisCritical limb ischemiaendothelial progenitor cellsmelatoninnitric oxide donorshock wave

Identifiers

PMID39398551
PMCPMC11470315

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.