ArticleAmerican journal of translational research2024
Association of anemia with postoperative cognitive decline and increased inflammatory markers in elderly gastrointestinal cancer patients.
Article in American journal of translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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5 authors.
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Abstract
objectiveTo investigate the association between postoperative cognitive dysfunction (POCD) and anemia in elderly patients with gastrointestinal tumors.
methodsA retrospective analysis was conducted on 184 elderly patients treated at Yanchang County People's Hospital from May 2019 to March 2022. The patients were divided into a normal hemoglobin group (n=109) and an anemia group (n=75) based on their preoperative hemoglobin levels. Cognitive function was assessed using MMSE and MoCA scales at preoperative day 1 and postoperative day 1, 3, and 7. Levels of S100β, TNF-α, and IL-6 were measured. Intraoperative data were recorded. POCD incidence was evaluated at 3 and 7 days postoperatively. Pearson correlation and ROC curve analyses were conducted, and logistic regression was conducted to identify risk factors for POCD.
resultsThe anemia group had significantly lower postoperative MMSE and MoCA scores and higher levels of inflammatory factors (all P<0.05) compared to the normal hemoglobin group. No significant differences in intraoperative data were observed between the groups (P>0.05). POCD incidence on postoperative day 3 and 7 was higher in the anemia group (38.66% and 30.67%) compared to that in the normal group (11.01% and 7.34%) (P<0.05). AUCs for hemoglobin levels in predicting POCD on postoperative day 3 and 7 were 0.858 and 0.865. Independent risk factors for POCD included age >70 years, education ≤6 years, and anemia.
conclusionsAnemia is associated with lower cognitive function scores, higher POCD incidence, and increased inflammatory factors in elderly gastrointestinal tumor patients after operation.
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