Evidence map›Paper›PMID 39398433›Full record

ArticleIJTLD open2024

Considering best practice standards for routine whole-genome sequencing for TB care and control.

J T Denholm, G de Vries, R Anthony, E Robinson, M Backx, I F Laurenson, A L Seagar, H Modestil, L Trieu, J S Meissner and 7 more

Abstract read
In one paragraph

Article in IJTLD open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Spatio-temporal patterns of tuberculosis revealed by routineThe Lancet regional health. Western Pacific · 2026
    Article
  4. Article
  5. Review
  6. Tracking the evolution of an extensively drug-resistant cross-borderEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Article
  7. Review
  8. Use of different genotyping methods to estimate TB transmission in the United States, 2020-2021.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2025
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

J T DenholmVictorian Tuberculosis Program, Melbourne, VIC, Australia.
G de VriesCentre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
R AnthonyCentre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
E RobinsonTB Unit and National Mycobacterial Reference Service, United Kingdom Health Security Agency, London, UK.
M BackxDepartment of Microbiology, University Hospital of Wales, Cardiff, UK.
I F LaurensonScottish Mycobacteria Reference Laboratory, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK.
A L SeagarScottish Mycobacteria Reference Laboratory, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK.
H ModestilNew York City Department of Health and Mental Hygiene, New York, NY, USA.
L TrieuNew York City Department of Health and Mental Hygiene, New York, NY, USA.
J S MeissnerNew York City Department of Health and Mental Hygiene, New York, NY, USA.
D H L NgNational Tuberculosis Programme, National Centre for Infectious Diseases, Singapore.
J Y TayNational Tuberculosis Programme, National Centre for Infectious Diseases, Singapore.
H H LinInstitute of Epidemiology and Preventive Medicine, National Taiwan University College of Public Health, Taiwan.
R LeeFaculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.
V SintchenkoNSW Mycobacterium Reference Laboratory, Institute of Clinical Pathology and Medical Research, NSW Health, Sydney, NSW, Australia.
B J MaraisSydney Infectious Diseases Institute, The University of Sydney, Sydney, NSW, Australia.
E J DonnanSydney Infectious Diseases Institute, The University of Sydney, Sydney, NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TB is a priority pathogen for the application of whole-genome sequencing (WGS) into routine public health practice. In low-incidence settings, a growing number of services have begun to incorporate routine WGS into standard practice. The increasing availability of real-time genomic information supports a variety of aspects of the public health response, including the detection of drug resistance, monitoring of laboratory and clinical practices, contact tracing investigations and active case finding. Optimal structures and approaches are needed to support the rapid translation of genomic information into practice and to evaluate outcomes and impact. In this consensus paper, we outline the elements needed to systemically incorporate routine WGS into the TB public health response, including the sustainability of services, multidisciplinary team models and monitoring and evaluation frameworks. If integrated in an efficient and thoughtful manner, routine WGS has the potential to significantly improve clinical TB care for individuals and the overall public health response.

Indexed as

cluster analysiscomputational biologygenomicsMycobacterium tuberculosispolicy makingpublic healthtuberculosis

Identifiers

PMID39398433
PMCPMC11467850

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.