Evidence map›Paper›PMID 39398415›Full record

ReviewFrontiers in pediatrics2024

Understanding necrotizing enterocolitis endotypes and acquired intestinal injury phenotypes from a historical and artificial intelligence perspective.

Alain Cuna, Navin Kumar, Venkatesh Sampath

Abstract readReview
In one paragraph

Review in Frontiers in pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alain CunaDivision of Neonatology, Children's Mercy Kansas City, Kansas City, MO, United States.
Navin KumarDivision of Neonatology, Hurley Medical Center, Flint, MI, United States.
Venkatesh SampathDivision of Neonatology, Children's Mercy Kansas City, Kansas City, MO, United States.

Funding

Single Immunoglobulin Interleukin-1 Related Receptor and necrotizing enterocolitis in premature infantsR01DK117296 · NIDDK · CHILDREN'S MERCY HOSP (KANSAS CITY, MO) · PI SAMPATH, VENKATESH, UMAR, SHAHID · 2018 to 2022
$2.6M
Gene-environment interactions in necrotizing enterocolitis: impact of SIGIRR mutation and gut microbiota on intestinal TLR hyperactivityK08DK125735 · NIDDK · CHILDREN'S MERCY HOSP (KANSAS CITY, MO) · PI CUNA, ALAIN · 2020 to 2024
$813k
NIDDK NIH HHS K08 DK125735NIDDK NIH HHS R01 DK117296
6 · The paper itself

Abstract

Necrotizing enterocolitis (NEC) remains a devastating disease in preterm and term neonates. Despite significant progress made in understanding NEC pathogenesis over the last 50 years, the inability of current definitions to discriminate the various pathophysiological processes underlying NEC has led to an umbrella term that limits clinical and research progress. In this mini review, we provide a historical perspective on how NEC definitions and pathogenesis have evolved to our current understanding of NEC endotypes. We also discuss how artificial intelligence-based approaches are influencing our knowledge of risk-factors, classification and prognosis of NEC and other neonatal intestinal injury phenotypes.

Indexed as

endotypemachine learningnecrotizing enterocolitisneonatephenotypeprematurity

Identifiers

PMID39398415
PMCPMC11466774

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.