Evidence map›Paper›PMID 39398351›Full record

ArticleClinical kidney journal2024

Cerebral white matter injury in haemodialysis patients: a cross-sectional tract-based spatial statistics and fixel-based analysis.

Yu Qi, Lijun Song, Xu Liu, Boyan Xu, Wenbo Yang, Mingan Li, Min Li, Zhengyang Zhu, Wenhu Liu, Zhenghan Yang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical kidney journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yu QiDepartment of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Lijun SongDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing China.
Xu LiuDepartment of Nephrology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Boyan XuMR Research, GE Healthcare, Beijing, China.
Wenbo YangDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing China.
Mingan LiDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing China.
Min LiClinical Epidemiology and EBM Unit, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Zhengyang ZhuDepartment of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Wenhu LiuDepartment of Nephrology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Zhenghan YangDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing China.
Zhenchang WangDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing China.
Hao WangDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: End-stage renal disease (ESRD) patients on maintenance haemodialysis (HD) often have damage to brain white matter (WM) and cognitive impairment. However, whether this damage is caused by maintenance HD or renal dysfunction is unclear. Herein we investigate the natural progression of WM damage in patients with ESRD and the effects of HD on WM using tract-based spatial statistics (TBSS) and fixel-based analysis (FBA). Methods: Eighty-one ESRD patients, including 41 with no dialysis (ND) and 40 on HD, and 46 healthy controls (HCs) were enrolled in this study. The differences in WM among the three groups [ESRD patients with HD (ESRD-HD), ESRD patients without HD (ESRD-ND) and HCs] were analysed using TBSS and FBA. Pairwise comparison was then used to compare the differences in WM between two groups. The relationships between WM and neurocognitive assessments/clinical data were analysed in ESRD patients with and without HD. Results: The damage to WM in ESRD-ND and ESRD-HD appeared around the lateral ventricles in TBSS, while FBA reflected that the changes had extended to adjacent WM in the anterior hemisphere, with a larger region in ESRD-HD compared with ESRD-ND and the brainstem was also widely affected in ESRD-HD. The Montreal Cognitive Assessment (MoCA) scores were lower in the ESRD-HD group. RD in the body of the corpus callosum were negatively correlated with MoCA scores in both groups. Fiber density and cross-section (FDC) in the left thalamo-prefrontal projection (T_PREFL) and left and right cingulum (CGL and CGR) were positively correlated with MoCA scores in both groups. Creatinine (Cr) was positively correlated with FDC in some frontal projection fibres in the striatum and thalamus, CG and fronto-pontine tract and was positively correlated with FD mainly in premotor projection fibres in the striatum and thalamus in the ESRD-HD group. Cr was negatively correlated with mean and radial diffusivity in regions of the corona radiata in the ESRD-ND group. Conclusions: FBA is more sensitive in detecting differences between ESRD patients and HCs. When ESRD patients receive maintenance HD, the degree of WM damage may not be aggravated, but the range of damaged WM may be expanded, especially in the anterior hemisphere and brainstem. Some of these changes in the anterior hemisphere may contribute to cognitive decline.

Indexed as

end-stage renal diseaseFBATBSSwhite matter

Identifiers

PMID39398351
PMCPMC11467692

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