Evidence map›Paper›PMID 39398243›Full record

ArticleiScience2024

Direct targeting of mitochondria by cisplatin leads to cytotoxicity in zebrafish lateral-line hair cells.

David S Lee, Angela Schrader, Jiaoxia Zou, Wee Han Ang, Mark E Warchol, Lavinia Sheets

Abstract read
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Antioxidants (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

David S LeeDepartment of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Angela SchraderDepartment of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jiaoxia ZouDepartment of Chemistry, National University of Singapore, Singapore 117543, Singapore.
Wee Han AngDepartment of Chemistry, National University of Singapore, Singapore 117543, Singapore.
Mark E WarcholDepartment of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Lavinia SheetsDepartment of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cisplatin is a chemotherapy drug that causes permanent hearing loss by injuring cochlear hair cells. Hair cell mitochondria have emerged as potential mediators of hair cell cytotoxicity. Using

Indexed as

biological sciencescancer systems biologynatural sciencespharmacologysystems biology

Identifiers

PMID39398243
PMCPMC11466657

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.