Evidence map›Paper›PMID 39398236›Full record

ArticleiScience2024

LETMD1 regulates mitochondrial protein synthesis and import to guard brown fat mitochondrial integrity and function.

Madigan Snyder, Yi-Kai Liu, Renjie Shang, Haowei Xu, Charlie Thrift, Xiyue Chen, Jingjuan Chen, Kun Ho Kim, Jiamin Qiu, Pengpeng Bi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Madigan SnyderDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA.
Yi-Kai LiuDepartment of Biochemistry, Purdue University, West Lafayette, IN 47907, USA.
Renjie ShangCenter for Molecular Medicine, University of Georgia, Athens, GA 30602, USA.
Haowei XuDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA.
Charlie ThriftDepartment of Biochemistry, Purdue University, West Lafayette, IN 47907, USA.
Xiyue ChenDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA.
Jingjuan ChenDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA.
Kun Ho KimDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA.
Jiamin QiuDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA.
Pengpeng BiCenter for Molecular Medicine, University of Georgia, Athens, GA 30602, USA.
W Andy TaoDepartment of Biochemistry, Purdue University, West Lafayette, IN 47907, USA.
Shihuan KuangDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA.

Funding

Immunomyoblasts in muscle regenerationR01AR078695 · NIAMS · PURDUE UNIVERSITY · PI KUANG, SHIHUAN · 2021 to 2025
$2.2M
Metabolic regulation of muscle satellite cell homeostasisR01DK132819 · NIDDK · PURDUE UNIVERSITY · PI Shihuan Kuang · 2023 to 2026
$2.0M
Targeting PTEN to ameliorate muscular dystrophy in a mouse modelR01AR079235 · NIAMS · PURDUE UNIVERSITY · PI KUANG, SHIHUAN · 2022 to 2025
$1.3M
NIAMS NIH HHS R01 AR078695NIAMS NIH HHS R01 AR079235NIDDK NIH HHS R01 DK132819
6 · The paper itself

Abstract

Thermogenic brown adipocytes (BAs) catabolize lipids to generate heat, representing powerful agents against the growing global obesity epidemic. We and others reported recently that LETMD1 is a BA-specific protein essential for mitochondrial structure and function, but the mechanisms of action remain unclear. We performed sequential digestion to demonstrate that LETMD1 is a trans-inner mitochondrial membrane protein. We then generated UCP1Cre-driven BA-specific

Indexed as

CellCell biologyCellular physiologyMolecular biology

Identifiers

PMID39398236
PMCPMC11467678

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.