Evidence map›Paper›PMID 39398224›Full record

ArticleMolecular therapy. Nucleic acids2024

DNA-PKcs inhibition improves sequential gene insertion of the full-length

Jacob T Stack, Rachael E Rayner, Reza Nouri, Carlos J Suarez, Sun Hee Kim, Karen L Kanke, Tatyana A Vetter, Estelle Cormet-Boyaka, Sriram Vaidyanathan

Abstract read
In one paragraph

Article in Molecular therapy. Nucleic acids, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. CRISPR for cystic fibrosis: Advances and insights from a systematic review.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jacob T StackCenter for Gene Therapy, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43215, USA.
Rachael E RaynerDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA.
Reza NouriCenter for Gene Therapy, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43215, USA.
Carlos J SuarezDepartment of Pathology, Stanford University, Palo Alto, CA 94305, USA.
Sun Hee KimDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA.
Karen L KankeCenter for Gene Therapy, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43215, USA.
Tatyana A VetterCenter for Gene Therapy, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43215, USA.
Estelle Cormet-BoyakaDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA.
Sriram VaidyanathanCenter for Gene Therapy, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43215, USA.

Funding

The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve HealthUL1TR002733 · NCATS · OHIO STATE UNIVERSITY · PI RINGEL, MATTHEW D · 2018 to 2022
$28.9M
A universal genome editing strategy to develop an airway stem cell therapy for cystic fibrosisR00HL151900 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI VAIDYANATHAN, SRIRAM · 2022 to 2024
$747k
NCATS NIH HHS UL1 TR002733NHLBI NIH HHS R00 HL151900
6 · The paper itself

Abstract

Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (

Indexed as

airway stem cell therapyCFTR genome editingCFTR super-exoncystic fibrosisDNA-PKcs inhibitionMT: RNA/DNA Editingsequential gene insertionuniversal CFTR correction

Identifiers

PMID39398224
PMCPMC11470261

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.