Evidence map›Paper›PMID 39398054›Full record

ArticleHeliyon2024

Hybrid fibrous architectures-mediated gene transfer by pDNA nanoparticles into macrophages.

Jana Ghitman, Gratiela Gradisteanu Pircalabioru, Calin Deleanu, Eugeniu Vasile, Ciprian Iliescu, Horia Iovu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jana GhitmanAdvanced Polymer Materials Group, National University of Science and Technology Politehnica Bucharest, 1-7 Gh. Polizu Street, 011061, Bucharest, Romania.
Gratiela Gradisteanu PircalabioruCenter of Excellence in Bioengineering - eBio-hub, National University of Science and Technology Politehnica Bucharest - CAMPUS, 6 Iuliu Maniu Boulevard, 061344, Bucharest, Romania.
Calin Deleanu"C. D. Nenitescu" Institute of Organic and Supramolecular Chemistry, 202B Splaiul Independentei, 060023 Bucharest, Romania.
Eugeniu VasileDepartment of Oxide Materials Science and Engineering, National University of Science and Technology Politehnica Bucharest, 1-7 Gh. Polizu, 060042, Bucharest, Romania.
Ciprian IliescuCenter of Excellence in Bioengineering - eBio-hub, National University of Science and Technology Politehnica Bucharest - CAMPUS, 6 Iuliu Maniu Boulevard, 061344, Bucharest, Romania.
Horia IovuAdvanced Polymer Materials Group, National University of Science and Technology Politehnica Bucharest, 1-7 Gh. Polizu Street, 011061, Bucharest, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gene therapy is one of the most potential therapeutic approaches in direct and specific regulation of biological functions of macrophages at the gene level for efficient cell therapy. However, the delivery of genetic material to macrophages is extremely challenging, because of low stability, specificity and inability of therapeutic genes to efficiently enter the cells. Here, we present a method that uses the hybrid electrospun architectures based on gelatin-alginate decorated with carboxylated graphene oxide (HAG/G) as efficient substrate for loading and

Indexed as

Hybrid electrospun architectureMacrophagesPEI/pDNA nanoparticlesTransient gene transfection

Identifiers

PMID39398054
PMCPMC11471199

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.