Evidence map›Paper›PMID 39397906›Full record

ArticleHeliyon2024

Tumor microbiota of renal cell carcinoma affects clinical prognosis by influencing the tumor immune microenvironment.

Hengyi Xu, Jingze Leng, Fengshuo Liu, Tianxiang Chen, Jiangming Qu, Yufan Yang, Chun Ning, Xindi Ke, Bin Xiao, Yanbin Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Microbiota and urinary tumor immunity: Mechanisms, therapeutic implications, and future perspectives.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hengyi XuDepartment of General Surgery, The First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, China.
Jingze LengSchool of Medicine, Tsinghua University, 100084, Beijing, China.
Fengshuo LiuPeking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100005, China.
Tianxiang ChenSchool of Medicine, Tsinghua University, 100084, Beijing, China.
Jiangming QuPeking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100005, China.
Yufan YangSchool of Medicine, Tsinghua University, 100084, Beijing, China.
Chun NingPeking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100005, China.
Xindi KePeking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100005, China.
Bin XiaoDepartment of Spine Surgery, Beijing Jishuitan Hospital, Affiliated Hospital of Capital Medicine University, 100035, Beijing, China.
Yanbin ZhangDepartment of Spine Surgery, Beijing Jishuitan Hospital, Affiliated Hospital of Capital Medicine University, 100035, Beijing, China.
Lejia SunDepartment of General Surgery, The First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite reported influences of the intratumoral microbiome on cancer progression, its role in this subtype remains unclear. This study aimed to characterize the microbial landscape and signatures of kidney renal clear cell carcinoma using RNA-Seq data from The Cancer Genome Atlas. Following microbial decontamination, differential microbial analysis was conducted between tumorous and adjacent non-tumorous samples. Compared to non-tumorous samples, tumorous microbiota exhibited reduced α and β diversity and distinct phylum-level communities. Differential microbial analysis between patients exhibiting long and short overall survival revealed ten significant differential microbial genera, with six genera correlating with a positive prognosis (

Indexed as

BiomarkersIntratumor microbiotaKidney renal clear cell carcinomaTumor microenvironment

Identifiers

PMID39397906
PMCPMC11470785

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.