ArticleHeliyon2024
A vitamin C-based natural deep eutectic solvent for the synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives.
Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Synthesis of Pyridines, Quinazolinones and Coumarins in Deep Eutectic Solvents: Principles, Methods and Applications.Molecules (Basel, Switzerland) · 2026Review
- Functionalized magnetic nanoparticles with deep eutectic solvents as efficient catalyst for the green synthesis of dihydroquinazolinones.Scientific reports · 2025Article
- A novel electrode design using Cu-TCPP MOF-modified MWCNT for efficient electro-organic cross coupling synthesis of biphenyl derivatives in a Urea/Chol-Cl DES system as a green and sustainable electrolyte.Scientific reports · 2025Article
- Accelerated synthesis of 3-dihydroquinazolin-4(1H)-one derivatives using nano-SiOScientific reports · 2025Article
- Design of natural asphalt sulfamic acid (NA-NHSOHeliyon · 2025Article
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4 authors.
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Abstract
Efficient and green protocols were reported to synthesize 2,3-dihydroquinazolin-4(1H)-one derivatives in natural deep eutectic solvent (NADES). NADES was prepared from ascorbic acid (AA) and choline chloride (ChCl) with reduced or null toxicity, biocompatibility, and low cost. The ChCl/AA NADES was successfully used in the synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives via the condensation reaction of aldehydes with 2-aminobenzamide and the three-component reactions of aldehydes, isatoic anhydrides and ammonium salts under solvent-free conditions. The scope of this method was evaluated by employing various aromatic, heterocyclic, and aliphatic aldehydes. The desired products were achieved in 85-97 % yield in a short reaction time. Also, the deep eutectic solvent ChCl/AA showed good recyclability and reusability.
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