Evidence map›Paper›PMID 39397887›Full record

ArticleCritical care research and practice2024

A Comparison of the Outcomes of COVID-19 Vaccinated and Nonvaccinated Patients Admitted to an Intensive Care Unit in a Low-Middle-Income Country.

Waleed Bin Ghaffar, Muhammad Faisal Khan, Moeed Bin Abdul Ghaffar, Muhammad Sohaib, Asma Rayani, Muhammad Mehmood Alam, Syed Talha Sibtain, Zahra Cheema, Asad Latif

Abstract read
In one paragraph

Article in Critical care research and practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Waleed Bin GhaffarDepartment of Anaesthesiology, Aga Khan University Hospital, Karachi P. O. Box 3500, Pakistan.ORCID https://orcid.org/0000-0002-9327-1015
Muhammad Faisal KhanDepartment of Anaesthesiology, Aga Khan University Hospital, Karachi P. O. Box 3500, Pakistan.ORCID https://orcid.org/0000-0002-3665-5215
Moeed Bin Abdul GhaffarDepartment of Surgery, Aga Khan University Hospital, Karachi P.O. Box 3500, Pakistan.ORCID https://orcid.org/0000-0002-1645-482X
Muhammad SohaibDepartment of Anaesthesiology, Aga Khan University Hospital, Karachi P. O. Box 3500, Pakistan.ORCID https://orcid.org/0000-0003-3748-4793
Asma RayaniDepartment of Medicine, Aga Khan University Hospital, Karachi P.O. Box 3500, Pakistan.ORCID https://orcid.org/0000-0003-4937-5092
Muhammad Mehmood AlamDepartment of Medicine, Aga Khan University Hospital, Karachi P.O. Box 3500, Pakistan.ORCID https://orcid.org/0000-0001-8182-3217
Syed Talha SibtainDepartment of Medicine, Aga Khan University Hospital, Karachi P.O. Box 3500, Pakistan.ORCID https://orcid.org/0000-0002-0841-940X
Zahra CheemaDepartment of Anaesthesiology, Aga Khan University Hospital, Karachi P. O. Box 3500, Pakistan.ORCID https://orcid.org/0000-0001-5062-1778
Asad LatifDepartment of Anaesthesiology, Aga Khan University Hospital, Karachi P. O. Box 3500, Pakistan.ORCID https://orcid.org/0000-0002-1298-1198

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients critically afflicted with coronavirus disease 2019 (COVID-19) often need intensive care unit (ICU) admission, despite comprehensive vaccination campaigns. The challenges faced by healthcare systems in low-middle-income countries, including limited infrastructure and resources, play a pivotal role in shaping the outcomes for these patients. This study aimed to meticulously compare outcomes between COVID-19 vaccinated and nonvaccinated patients admitted to the ICU. In addition, demographic factors and the ICU course influencing mortality were also assessed. A retrospective review of records from the COVID-ICU of Aga Khan University Hospital spanning July 2021-March 2022 included 133 patients. Statistical analyses, encompassing the Mann-Whitney U-test and chi-square/Fisher exact test, discerned quantitative and qualitative differences. Stepwise multivariable logistic regression models with forward selection identified factors associated with hospital mortality. Results revealed comparable cohorts: vaccinated (48.13%) and nonvaccinated (51.87%). Vaccinated individuals, characterized by advanced age and higher Charlson Comorbidity Index, exhibited more critical disease (89.1%;

Indexed as

acute kidney injuryadult respiratory distress syndromeCOVID-19COVID-19 vaccinescritical care outcomeshealthcare-associated pneumoniarespiratory insufficiency

Identifiers

PMID39397887
PMCPMC11469933

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.