Evidence map›Paper›PMID 39397866›Full record

ArticleFrontiers in cellular and infection microbiology2024

Parallel evolution of fluconazole resistance and tolerance in

Lijun Zheng, Yi Xu, Chen Wang, Yubo Dong, Liangsheng Guo

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Global surveillance ofAntimicrobial agents and chemotherapy · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Fluconazole tolerance and virulence adaptations ofJournal of oral microbiology · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Dual adaptive strategies inFrontiers in microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lijun Zheng *Department of Ultrasound Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Yi Xu *Department of Pharmacy, The 960th Hospital of PLA, Jinan, China.
Chen WangDepartment of Pharmacy, The 960th Hospital of PLA, Jinan, China.
Yubo DongDepartment of Pharmacy, The 960th Hospital of PLA, Jinan, China.
Liangsheng GuoDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: With the growing population of immunocompromised individuals, opportunistic fungal pathogens pose a global health threat. Objective: This study investigates how Methods: This study compared the factors regulating fluconazole tolerance between Results: We found temperature modulated tolerance in the opposite way in Conclusion: This study highlights that while tolerance to fluconazole is a common response in

Indexed as

Antifungal AgentsCandida glabrataDrug Resistance, FungalFluconazoleMicrobial Sensitivity TestsCalcineurinCandida albicansDrug ToleranceFungal ProteinsHSP90 Heat-Shock ProteinsMutationTemperatureAntifungal AgentsCalcineurinFluconazoleFungal ProteinsHSP90 Heat-Shock Proteinsantifungal resistanceantifungal tolerancecalcineurinCandida glabrataevolution trajectoryHsp90

Identifiers

PMID39397866
PMCPMC11466938

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.