Evidence map›Paper›PMID 39397798›Full record

ArticleFrontiers in microbiology2024

Genomic profiling and spatial SEIR modeling of COVID-19 transmission in Western New York.

Jonathan E Bard, Na Jiang, Jamaal Emerson, Madeleine Bartz, Natalie A Lamb, Brandon J Marzullo, Alyssa Pohlman, Amanda Boccolucci, Norma J Nowak, Donald A Yergeau and 2 more

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jonathan E Bard *Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, United States.
Na Jiang *Department of Geography, State University of New York at Buffalo, Buffalo, NY, United States.
Jamaal EmersonDepartment of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, United States.
Madeleine BartzGenomics and Bioinformatics Core, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, United States.
Natalie A LambNational Renewable Energy Laboratory, Golden, CO, United States.
Brandon J MarzulloGenomics and Bioinformatics Core, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, United States.
Alyssa PohlmanGenomics and Bioinformatics Core, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, United States.
Amanda BoccolucciGenomics and Bioinformatics Core, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, United States.
Norma J NowakDepartment of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, United States.
Donald A YergeauGenomics and Bioinformatics Core, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, United States.
Andrew T CrooksDepartment of Geography, State University of New York at Buffalo, Buffalo, NY, United States.
Jennifer A SurteesDepartment of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, United States.

Funding

Mentoring For Success: Teaching Faculty Fundamental Skills For Attracting, Admitting and Developing StudentsT32GM144920 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Margarita L Dubocovich · 2022 to 2026
$3.1M
NIGMS NIH HHS T32 GM144920
6 · The paper itself

Abstract

The COVID-19 pandemic has prompted an unprecedented global effort to understand and mitigate the spread of the SARS-CoV-2 virus. In this study, we present a comprehensive analysis of COVID-19 in Western New York (WNY), integrating individual patient-level genomic sequencing data with a spatially informed agent-based disease Susceptible-Exposed-Infectious-Recovered (SEIR) computational model. The integration of genomic and spatial data enables a multi-faceted exploration of the factors influencing the transmission patterns of COVID-19, including genetic variations in the viral genomes, population density, and movement dynamics in New York State (NYS). Our genomic analyses provide insights into the genetic heterogeneity of SARS-CoV-2 within a single lineage, at region-specific resolutions, while our population analyses provide models for SARS-CoV-2 lineage transmission. Together, our findings shed light on localized dynamics of the pandemic, revealing potential cross-county transmission networks. This interdisciplinary approach, bridging genomics and spatial modeling, contributes to a more comprehensive understanding of COVID-19 dynamics. The results of this study have implications for future public health strategies, including guiding targeted interventions and resource allocations to control the spread of similar viruses.

Indexed as

New York Statenext-generation genome sequencingSARS-CoV-2SARS-CoV-2 transmission dynamicsspatial SEIR model

Identifiers

PMID39397798
PMCPMC11468862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.