Evidence map›Paper›PMID 39397761›Full record

ArticleEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2024

Carotid sinus massage in clinical practice: the Six-Step-Method.

Frederik J de Lange, Jelle S Y de Jong, Steven van Zanten, Willem P M E Hofland, Rick Tabak, Marianne Cammenga, Jaume Francisco-Pascual, Vincenzo Russo, Artur Fedorowski, Jean-Claude Deharo and 1 more

Abstract readVideo-Audio Media
In one paragraph

Article in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Neurocardiology - from basics to clinic.World journal of cardiology · 2025
    Review
  4. Article
  5. Pathophysiological aspects of carotid sinus massage.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  6. Carotid sinus massage in clinical practice.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Frederik J de LangeDepartment of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Heart Centre, Amsterdam Cardiovascular Sciences, Meibergdreef 9, 1105 AZ, The Netherlands.ORCID 0000-0002-7590-9230
Jelle S Y de JongDepartment of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Heart Centre, Amsterdam Cardiovascular Sciences, Meibergdreef 9, 1105 AZ, The Netherlands.ORCID 0000-0001-9522-2455
Steven van ZantenDepartment of Cardiology, Reinier de Graaf Gasthuis, Delft, The Netherlands.ORCID 0009-0005-1784-9558
Willem P M E HoflandDepartment of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Heart Centre, Amsterdam Cardiovascular Sciences, Meibergdreef 9, 1105 AZ, The Netherlands.ORCID 0000-0001-9675-4082
Rick TabakDepartment of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Heart Centre, Amsterdam Cardiovascular Sciences, Meibergdreef 9, 1105 AZ, The Netherlands.
Marianne CammengaDepartment of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Heart Centre, Amsterdam Cardiovascular Sciences, Meibergdreef 9, 1105 AZ, The Netherlands.
Jaume Francisco-PascualUnitat d'Arritmies, Servei de Cardiologia, Hospital Universitari Vall Hebrón i Vall d'Hebron Research Institut, Universitat Autònoma de Barcelona, CIBER-CV, Barcelona, Spain.ORCID 0000-0002-8841-2581
Vincenzo RussoDepartment of Translational Medical Sciences, Cardiology Unit, University of Campania 'Luigi Vanvitelli', Monaldi Hospital, Naples, Italy.ORCID 0000-0002-9227-0360
Artur FedorowskiDepartment of Cardiology, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0002-5352-6327
Jean-Claude DeharoAssistance Publique-Hôpitaux de Marseille, Centre Hospitalier Universitaire La Timone, Service de Cardiologie, France and Aix Marseille Université, C2VN, 13005 Marseille, France.ORCID 0000-0002-1534-3845
Michele BrignoleDepartment of Cardiology, IRCCS Istituto Auxologico Italiano, Faint & Fall Research Centre, San Luca Hospital, Milan, Italy.ORCID 0000-0002-1845-5607

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carotid sinus massage (CSM) as integral part of cardiovascular autonomic testing is indicated in all patients > 40 years with syncope of unknown origin and suspected reflex mechanism. However, large practice variation exists in performing CSM that inevitably affects the positivity rate of the test and may result in an inaccurate diagnosis in patients with unexplained syncope. Even though CSM was introduced into medical practice more than 100 years ago, the method of performing CSM is still largely operator- and centre-dependent, while in many places, the test has been entirely abandoned. Here, we describe a standardized protocol on how to perform CSM, which basic monitoring equipment is necessary and why CSM is a safe procedure to perform. Our aim is to create a uniform approach to perform CSM. The new proposed algorithm, the Six-Step-Method, includes: (i) check history for exclusion CSM; (ii) turn head slightly contralaterally and posterior (see also explanatory video and poster provided as Supplementary material; (iii) palpation to identify carotid sinus location; (iv) massage for 10 s; (v) monitoring of blood pressure and heart rate to assess of the haemodynamic response type; and (vi) include time intervals between subsequent massages. Carotid sinus massage should be performed on both the left and right and in the supine and upright position. The recommended equipment to perform CSM consists of: (i) a tilt table in order to perform CSM in supine and standing position, (ii) a continuous blood pressure monitor or cardiac monitor, and (iii) at least two persons.

Indexed as

Carotid SinusHeart RateMassageAlgorithmsAutonomic Nervous SystemBlood PressureHeart MassageHemodynamicsHumansMedical History TakingPalpationPredictive Value of TestsSyncopeTime FactorsCarotid sinus massageHaemodynamic monitoringSyncopeTilt table testingVideo recording

Identifiers

PMID39397761
PMCPMC11544318

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.