Evidence map›Paper›PMID 39397695›Full record

SynthesisEuropean psychiatry : the journal of the Association of European Psychiatrists2024

Specificity in the commonalities of inhibition control: using meta-analysis and regression analysis to identify the key brain regions in psychiatric disorders.

Li Wan, Pingting Pei, Qinghui Zhang, Wenxiang Gao

Abstract readMeta-AnalysisReview
In one paragraph

Synthesis in European psychiatry : the journal of the Association of European Psychiatrists, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Li WanAffiliated Psychological Hospital of Anhui Medical University; Anhui Mental Health Center; Hefei Fourth People's Hospital, Hefei, China.ORCID 0000-0002-3748-9087
Pingting PeiDepartment of Psychology, Anhui University, Hefei, China.
Qinghui ZhangAffiliated Psychological Hospital of Anhui Medical University; Anhui Mental Health Center; Hefei Fourth People's Hospital, Hefei, China.
Wenxiang GaoAffiliated Psychological Hospital of Anhui Medical University; Anhui Mental Health Center; Hefei Fourth People's Hospital, Hefei, China.

Funding

Anhui Health Commission Research Project AHWJ2022B095Anhui Province Key Research and Development Project 202204295107020004Hefei Municipal Health Commission Applied Medicine Research Project HWK2022ZD015Key Laboratory of Philosophy and Social Science of Anhui Province on Adolescent Mental Health and Crisis Intelligence Intervention Open Fund SYS2023A04National Clinical Key Specialty Construction Project of China
6 · The paper itself

Abstract

backgroundThe differential diagnosis of psychiatric disorders is relatively challenging for several reasons. In this context, we believe that task-based magnetic resonance imaging (MRI) can serve as a tool for differential diagnosis. The aim of this study was to explore the commonalities in brain activities among individuals with psychiatric disorders and to identify the key brain regions that can distinguish between these disorders.

methodsThe PubMed, MEDLINE, EMBASE, Web of Science, Scopus, PsycINFO, and Google Scholar databases were searched for whole-brain functional MRI studies that compared psychiatric patients and normal controls. The psychiatric disorders included schizophrenia (SCZ), bipolar disorder (BD), major depressive disorder (MDD), obsessive-compulsive disorder, attention-deficit/hyperactivity disorder (ADHD), and autism spectrum disorder (ASD). Studies using go-nogo paradigms were selected, we then conducted activation likelihood estimation (ALE) meta-analysis, factor analysis, and regression analysis on these studies subsequently.

resultsA total of 152 studies (108 with patients) were selected and a consistent pattern was found, that is, decreased activities in the same brain regions across six disorders. Factor analysis clustered six disorders into three pairs: SCZ and ASD, MDD and BD, and ADHD and BD. Furthermore, the heterogeneity of SCZ and ASD was located in the left and right thalamus; and the heterogeneity of MDD and BD was located in the thalamus, insula, and superior frontal gyrus.

conclusionThe results can lead to a new classification method for psychiatric disorders, benefit the differential diagnosis at an early stage, and help to understand the biobasis of psychiatric disorders.

Indexed as

BrainMagnetic Resonance ImagingMental DisordersDiagnosis, DifferentialHumansInhibition, PsychologicalRegression AnalysisALE meta-analysisclustering centerfactor analysisinhibition controlpsychiatric disorders

Identifiers

PMID39397695
PMCPMC11730059

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.