Observational studyMedical science monitor : international medical journal of experimental and clinical research2024
Evaluation of Neuromuscular Blockade: A Comparative Study of TOF-Cuff® on the Lower Leg and TOF-Scan® on the Ulnar Nerve During Mivacurium Anesthesia.
Observational study in Medical science monitor : international medical journal of experimental and clinical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Muscle-Specific Differences in Neuromuscular Block and Quantitative Neuromuscular Monitoring: A Narrative Review.Medical science monitor : international medical journal of experimental and clinical research · 2026Review
- Narrative Review of the Role of Nondepolarizing Neuromuscular Blocking Agents in Anesthesia: Perspective 2026.Medical science monitor : international medical journal of experimental and clinical research · 2026Review
- Age-Specific Pharmacology of Neuromuscular Blocking Agents: A Comprehensive Review.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Advances in Neuromuscular Monitoring Techniques in Anesthesiology: A 2025 Perspective.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Comparison of TOF scan neuromuscular monitoring on adductor pollicis vs. corrugator supercilii and flexor hallucis brevis.Scientific reports · 2025Observational
- Skeletal Muscle Relaxants and Their Impact on Intracranial Pressure in Neurosurgery.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Neuromuscular Blocking Agents and Reversal Agents Usage, and Neuromuscular Blockade Monitoring in the Intensive Care Unit - Review Article.International journal of general medicine · 2025Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND To evaluate neuromuscular monitoring during anesthesia with mivacurium, this study assessed the correlation between measurements of TOF-Cuff® placed on the lower leg and stimulating the tibial nerve and TOF-Scan® values from the adductor pollicis muscle. Additionally, systolic (SBP) and diastolic (DBO) blood pressure measured in both locations were compared. MATERIAL AND METHODS Twenty-six patients participated in this observational clinical trial. The TOF-Cuff® was placed on the lower leg and the TOF-Scan® was placed on the thumb. Train-of-four (TOF) values were recorded simultaneously by both devices at 30-second intervals before intubation. Measurements continued every 5 minutes until extubation. Bland-Altman analyses compared TOF values obtained from the 2 devices. RESULTS Time to onset and relaxation time did not differ significantly; the number of patients presenting a lack of blockade despite TOF=0 was also concordant. The time from the last dose of mivacurium to TOF ratio >90 was shorter on the leg than on hand (median 20 [5-28, 0-65] min vs 30 [20-35, 0-60] min, p=0.025). The median (range, interquartile range) difference between measurements was: 11.6 (-41 to 45, 2-19) for SBP and -8 (-28 to 26, -15 to -4) for DBP at baseline (p=0.0495); 5 (-53 to 55, -2 to 9) for SBP and -11 (-45 to 29, -19 to -5) (p=0.0017) for DBP during the blockade. CONCLUSIONS Time-to-onset and SBP are comparable between these 2 methods, in contrast to time-to-recovery and diastolic blood pressure, and this should be considered in case of the inability to apply the TOF-Cuff on the leg.
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