ArticleBMC public health2024
Association between body fat variation rate and risk of diabetic nephropathy - a posthoc analysis based on ACCORD database.
Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Causal insights into major risk factors for diabetic kidney disease: a comprehensive meta-analysis and Mendelian randomization study.Renal failure · 2025Pooled it
- Effects of diabetes complications on body composition, dietary intake, and metabolic parameters.Acta diabetologica · 2026Article
- Association of BMI Change with New-Onset or Progressive Diabetic Kidney Disease in People with Normal-Weight Type 2 Diabetes.Journal of clinical medicine · 2026Article
- Impact of Body Mass Index Variability on Kidney Disease Progression in a Large Type 1 Diabetes Cohort.Diabetes/metabolism research and reviews · 2026Article
- Type 5 diabetes mellitus: nutritional-imprinted β-cell insufficiency, diagnostic gaps, and emerging therapeutic strategies.Frontiers in endocrinology · 2026Review
- The Obesity-Related Indices Are Useful for Predicting Diabetic Nephropathy in Patients With Type II Diabetes Mellitus: A Retrospective Cohort Study of NHANES.Endocrinology, diabetes & metabolism · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundWeight control has consistently been regarded as a significant preventive measure against diabetic nephropathy. however, the potential impact of substantial fluctuations in body fat during this process on the risk of diabetic nephropathy remains uncertain. This study aimed to investigate the association between body fat variation rate and diabetic nephropathy incident in American patients with type 2 diabetes.
methodsThe study used data from the Action to Control Cardiovascular Risk in diabetes (ACCORD) trial to calculate body fat variation rates over two years and divided participants into Low and High groups. The hazard ratio and 95% confidence interval were estimated using a Cox proportional hazards model, and confounding variables were addressed using propensity score matching.
resultsFour thousand six hundred nine participants with type 2 diabetes were studied, with 1,511 cases of diabetic nephropathy observed over 5 years. High body fat variation rate was linked to a higher risk of diabetic nephropathy compared to low body fat variation rate (HR 1.13, 95% CI 1.01-1.26). Statistically significant interaction was observed between body fat variation rate and BMI (P interaction = 0.008), and high level of body fat variation rate was only associated with increased risk of diabetic nephropathy in participants with BMI > 30 (HR 1.34 and 95% CI 1.08-1.66).
conclusionsAmong participants with Type 2 Diabetes Mellitus, body fat variation rate was associated with increased risk of diabetic nephropathy. Furthermore, the association was modified by BMI, and positive association was demonstrated in obese but not non-obese individuals. Consequently, for obese patients with diabetes, a more gradual weight loss strategy is recommended to prevent drastic fluctuations in body fat.
trial registrationClinical Trials. gov, no. NCT000000620 (Registration Date 199909).
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