Evidence map›Paper›PMID 39396912›Full record

ArticleAge and ageing2024

Core outcome set for studies evaluating interventions to prevent or treat delirium in long-term care older residents: international key stakeholder informed consensus study.

Gregor Russell, Namrata Rana, Siobhan T Reilly, Anas Shehadeh, Valerie Page, Najma Siddiqi, Louise Rose

Abstract readConsensus Statement
In one paragraph

Article in Age and ageing, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gregor RussellOsprey House, Lynfield Mount Hospital, Bradford District Care NHS Foundation Trust, Heights Lane, Bradford BD9 6PD, United Kingdom.ORCID 0000-0001-9449-2824
Namrata RanaCity Hospital campus, Nottingham University Hospitals NHS Trust, Hucknall Rd, Nottingham NG5 1PB, United Kingdom.
Siobhan T ReillyCentre for Applied Dementia Studies, Faculty of Health Studies, University of Bradford, Richmond Rd, Bradford BD7 1DP, United Kingdom.
Anas ShehadehCentre for Applied Dementia Studies, Faculty of Health Studies, University of Bradford, Richmond Rd, Bradford BD7 1DP, United Kingdom.ORCID 0000-0002-0076-2852
Valerie PageDepartment of Critical Care, Watford General Hospital, Vicarage Rd, Watford, Hertfordshire WD18 0HB, United Kingdom.
Najma SiddiqiDepartment of Health Sciences, University of York-Medical School Siwards Way, Heslington, York YO10 5DD, United Kingdom.ORCID 0000-0003-1794-2152
Louise RoseFaculty of Nursing, Midwifery and Palliative Care, King's College London, 57 Waterloo Rd, London SE1 8WA, United Kingdom.

Funding

CIHRKing's College LondonNHS Research Ethic Committee London- WestminsterResearch Ethics Boards of the University of TorontoSunnybrook Health Sciences Centre
6 · The paper itself

Abstract

backgroundTrials of interventions to prevent or treat delirium in older adults resident in long-term care settings (LTC) report heterogenous outcomes, hampering the identification of effective management strategies for this important condition. Our objective was to develop international consensus among key stakeholders for a core outcome set (COS) for future trials of interventions to prevent and/or treat delirium in this population.

methodsWe used a rigorous COS development process including qualitative interviews with family members and staff with experience of delirium in LTC; a modified two-round Delphi survey; and virtual consensus meetings using nominal group technique. The study was registered with the Core Outcome Measures in Effectiveness Trials (COMET) initiative (https://www.comet-initiative.org/studies/details/796).

resultsItem generation identified 22 delirium-specific outcomes and 32 other outcomes from 18 qualitative interviews. When combined with outcomes identified in our earlier systematic review, and following an item reduction step, this gave 43 outcomes that advanced to the formal consensus processes. These involved 169 participants from 12 countries, and included healthcare professionals (121, 72%), researchers (24, 14%), and family members/people with experience of delirium (24, 14%). Six outcomes were identified as essential to include in all trials of interventions for delirium in LTC, and were therefore included in the COS. These are: 'delirium occurrence'; 'delirium related distress'; 'delirium severity'; 'cognition including memory', 'admission to hospital' and 'mortality'.

conclusionsThis COS, endorsed by the American Delirium Society and the European and Australasian Delirium Associations, is recommended for use in future clinical trials evaluating delirium prevention or treatment interventions for older adults residing in LTC.

Indexed as

DeliriumDelphi TechniqueLong-Term CareStakeholder ParticipationAgedAged, 80 and overEndpoint DeterminationFemaleHomes for the AgedHumansMaleNursing HomesTreatment Outcomecore outcome setdeliriuminterventionslong-term careolder peopleoutcomes

Identifiers

PMID39396912
PMCPMC11471312

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.