Evidence map›Paper›PMID 39396814›Full record

ArticleBritish journal of haematology2024

Outcomes of frail patients undergoing high-dose chemotherapy and autologous stem cell transplantation for multiple myeloma.

Stephanie Yohay, Temitope Oloyede, Soyoung Kim, Xi Fang, Binod Dhakal, Ayesha Aijaz, Meera Mohan, Ravi Narra, Marcelo Pasquini, Anita D'Souza and 3 more

Abstract read
In one paragraph

Article in British journal of haematology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Stephanie YohayMedical College of Wisconsin, Milwaukee, Wisconsin, USA.ORCID https://orcid.org/0009-0008-9108-177X
Temitope OloyedeCenter for International Blood and Marrow Transplantation, Milwaukee, Wisconsin, USA.
Soyoung KimCenter for International Blood and Marrow Transplantation, Milwaukee, Wisconsin, USA.
Xi FangYale University, New Haven, Connecticut, USA.
Binod DhakalMedical College of Wisconsin, Milwaukee, Wisconsin, USA.ORCID https://orcid.org/0000-0002-4377-9742
Ayesha AijazWe Care Scan Center, Srinagar, Kashmir, India.
Meera MohanMedical College of Wisconsin, Milwaukee, Wisconsin, USA.ORCID https://orcid.org/0000-0002-6913-6526
Ravi NarraMedical College of Wisconsin, Milwaukee, Wisconsin, USA.
Marcelo PasquiniMedical College of Wisconsin, Milwaukee, Wisconsin, USA.ORCID https://orcid.org/0000-0003-1579-2293
Anita D'SouzaMedical College of Wisconsin, Milwaukee, Wisconsin, USA.ORCID https://orcid.org/0000-0002-1092-5643
Mehdi HamadaniMedical College of Wisconsin, Milwaukee, Wisconsin, USA.ORCID https://orcid.org/0000-0001-5372-510X
Ciara Louise FreemanMoffitt Cancer Center, Tampa, Florida, USA.
Othman Salim AkhtarMedical College of Wisconsin, Milwaukee, Wisconsin, USA.ORCID https://orcid.org/0000-0003-1673-9670

Funding

Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
NTP INFORMATION SYSTEMS SUPPORT27305C0011 · NIEHS · Z-TECH CORPORATION · 2007 to 2009
$4.3M
PROVIDE RABBITS, RATS, MICE, HAMSTERS, GERBILS, GUINEA PIGS27307C0011 · NIEHS · PI BOLEN, WAYNE · 2007 to 2007
$500k
Health Resources and Services Administration (HRSA) 75R60222C00011National Cancer Institute (NCI) U24CA076518National Heart, Lung and Blood Institute (NHLBI)National Institute of Allergy and Infectious Diseases (NIAID)NCI NIH HHS U24 CA076518NIEHS NIH HHS 27305C0011NIEHS NIH HHS 27307C0011NIEHS NIH HHS 27398C0011Office of Naval Research N00014-21-1-2954Office of Naval Research N00014-23-1-2057
6 · The paper itself

Abstract

In patients with multiple myeloma (MM) not-eligible for autologous haematopoietic cell transplantation (autoHCT), a simplified frailty index (SFI) identifies frail patients at risk for poor outcomes, but data are limited for transplant-eligible patients. In this registry-based retrospective study, we used an adapted version of the SFI to determine the prevalence of frailty in patients ≥65 years of age with MM undergoing autoHCT. Out of 5563 patients, 37.9% of patients were classified as frail and although they had increased non-relapse mortality (NRM) and inferior overall survival, the NRM at 100 days remained low (<2%) compared with non-frail patients.

Indexed as

Hematopoietic Stem Cell TransplantationMultiple MyelomaTransplantation, AutologousAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsFemaleFrailtyHumansMaleRetrospective StudiesTreatment Outcomeautologous stem cell transplantationBMTfrailtymultiple myelomasurvival

Identifiers

PMID39396814
PMCPMC12714362

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.