Evidence map›Paper›PMID 39396521›Full record

ArticleImmunity2024

Autoimmune CD4

Nouf Aljobaily, Denise Allard, Bryant Perkins, Arielle Raugh, Tessa Galland, Yi Jing, W Zac Stephens, Matthew L Bettini, J Scott Hale, Maria Bettini

Abstract read
In one paragraph

Article in Immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. TOX drives CD4Nature immunology · 2026
    Article
  5. The dual role of TOX in regulating TNature immunology · 2026
    Article
  6. Article
  7. Antigen-specific immunotherapy with a CD4Nature communications · 2026
    Article
  8. Article
  9. Regulators of CD8Nature reviews. Immunology · 2026
    Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nouf AljobailyDepartment of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, UT 84112, USA.
Denise AllardDepartment of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, UT 84112, USA.
Bryant PerkinsDepartment of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, UT 84112, USA.
Arielle RaughDepartment of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, UT 84112, USA.
Tessa GallandDepartment of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, UT 84112, USA.
Yi JingDepartment of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, UT 84112, USA.
W Zac StephensDepartment of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, UT 84112, USA.
Matthew L BettiniDepartment of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, UT 84112, USA.
J Scott HaleDepartment of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, UT 84112, USA.
Maria BettiniDepartment of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, UT 84112, USA. Electronic address: maria.bettini@path.utah.edu.

Funding

Mechanisms of T cell persistence during chronic autoimmunityR01AI175494 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Maria Bettini · 2024 to 2026
$2.0M
Self-Reactive T Cell Development in Type 1 DiabetesR01DK114456 · NIDDK · UNIVERSITY OF UTAH · PI BETTINI, MATTHEW · 2018 to 2022
$1.9M
From genomics to natural language processing: A protected environment for research computing in the health scienceS10OD021644 · OD · UNIVERSITY OF UTAH · PI CHEATHAM, THOMAS E. · 2017 to 2017
$494k
NIAID NIH HHS R01 AI175494NIDDK NIH HHS R01 DK114456NIH HHS S10 OD021644
6 · The paper itself

Abstract

Self-reactive T cells experience chronic antigen exposure but do not exhibit signs of exhaustion. Here, we investigated the mechanisms for sustained, functioning autoimmune CD4

Indexed as

CD4-Positive T-LymphocytesDiabetes Mellitus, Type 1Hepatocyte Nuclear Factor 1-alphaAnimalsAutoimmunityCell DifferentiationDNA MethylationEpigenesis, GeneticLymphocyte ActivationMiceMice, Inbred NODT Cell Transcription Factor 1Hepatocyte Nuclear Factor 1-alphaHnf1a protein, mouseT Cell Transcription Factor 1autoimmunityCD4(+) T cellexhaustionTCF1type 1 diabetes

Identifiers

PMID39396521
PMCPMC11563894

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.