Evidence map›Paper›PMID 39396193›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2025

Human mesenchymal stem/stromal cell-derived extracellular vesicle transport in meniscus fibrocartilage.

Gabi Schwartz, Samir Rana, Alicia R Jackson, Clarissa Leñero, Thomas M Best, Dimitrios Kouroupis, Francesco Travascio

Abstract read
In one paragraph

Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. [Advances in immunomodulatory strategies for meniscal regeneration].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Review
  2. Review
  3. 80 years of extracellular vesicles: from discovery to clinical translation.Extracellular vesicles and circulating nucleic acids · 2026
    Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gabi SchwartzDepartment of Biomedical Engineering, University of Miami, Coral Gables, USA.
Samir RanaDepartment of Kinesiology and Sports Sciences, University of Miami, Coral Gables, USA.
Alicia R JacksonDepartment of Biomedical Engineering, University of Miami, Coral Gables, USA.
Clarissa LeñeroDepartment of Orthopedics, UHealth Sports Medicine Institute, Miller School of Medicine, University of Miami, Miami, USA.
Thomas M BestDepartment of Biomedical Engineering, University of Miami, Coral Gables, USA.
Dimitrios KouroupisDepartment of Orthopedics, UHealth Sports Medicine Institute, Miller School of Medicine, University of Miami, Miami, USA.ORCID 0000-0002-3892-9013
Francesco TravascioDepartment of Orthopedics, UHealth Sports Medicine Institute, Miller School of Medicine, University of Miami, Miami, USA.ORCID 0000-0002-9301-9266

Funding

Novel Computational Biomechanics Approach to Design of Bioengineered Tissue Construct for Meniscus Defect RepairR01AR073222 · NIAMS · UNIVERSITY OF MIAMI CORAL GABLES · PI JACKSON, ALICIA R, TRAVASCIO, FRANCESCO · 2018 to 2021
$1.3M
CD10-bound Exosomes from IFP-MSC Degrade Substance P Controlling OA Inflammation and PainR21AR080388 · NIAMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI KOUROUPIS, DIMITRIOS · 2022 to 2023
$371k
NIAMS NIH HHS 1R01AR073222NIAMS NIH HHS R01 AR073222NIAMS NIH HHS R21 AR080388NIAMS NIH HHS R21AR080388
6 · The paper itself

Abstract

Extracellular vesicles (EVs) derived from endometrial-derived mesenchymal stem/stromal cells (eMSC) play a crucial role in tissue repair due to their immunomodulatory and reparative properties. Given these properties, eMSC EVs may offer potential benefits for meniscal repair. The meniscus, being partly vascularized, relies on diffusivity for solute trafficking. This study focuses on EVs transport properties characterization within fibrocartilage that remains unknown. Specifically, EVs were isolated from Crude and CD146

Indexed as

Extracellular VesiclesFibrocartilageMeniscusMesenchymal Stem CellsAnimalsCD146 AntigenEndometriumFemaleHumansSwineCD146 Antigenexosomefluorescence recovery after photobleachingtransport phenomena

Identifiers

PMID39396193
PMCPMC11703673

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.