SynthesisMedicina oral, patologia oral y cirugia bucal2024
Prognostic value of systemic immune-inflammation index and systemic inflammation response index for oral cancers: A systematic review and meta-analysis.
Synthesis in Medicina oral, patologia oral y cirugia bucal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Prognostic and clinicopathological impact of systemic inflammation response index (SIRI) on patients with esophageal cancer: a meta-analysis.Systematic reviews · 2025Pooled it
- Prognostic value of systemic inflammation response index in patients with glioma: a meta-analysis.Frontiers in immunology · 2025Pooled it
- Value of CRP, albumin, and lymphocyte index in predicting survival of patients with gastrointestinal malignancies: a systematic review and meta-analysis.Frontiers in oncology · 2025Pooled it
- Value of different nutritional and inflammatory markers for diagnosis of peritonitis in patients undergoing peritoneal dialysis.Renal failure · 2026Article
- The predictive value of systemic inflammation response index and albumin-to-globulin ratio for prognosis in non-small cell lung cancer.Scientific reports · 2026Article
- Relationship between systemic immune-inflammation index and risk of mortality among pneumonia patients: a systematic review with meta-analysis.Journal of thoracic disease · 2026Article
- Non-Smoking, Non-Drinking Oral Squamous Cell Carcinoma Is Associated with an Immune-Modulated Clinical Phenotype.Cancers · 2026Article
- Visit‑to‑visit variability of inflammation-immunity indices and prognosis in hepatocellular carcinoma.BMC gastroenterology · 2025Article
- Prognostic significance of systemic immune inflammation index and systemic inflammation response index for cervical cancer: A systematic review and meta-analysis.Pakistan journal of medical sciences · 2025Article
- Association between the inflammatory burden index and erectile dysfunction: a cross-sectional study based on NHANES 2001-2004.Journal of health, population, and nutrition · 2025Article
- Article
- Preoperative Systemic Inflammation Response Index Predicts Survival Outcome for Previously Irradiated Metachronous Secondary Head and Neck Cancer Patients.Cancer management and research · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) are commonly used prognostic indicators for a variety of cancers. However, their utility in oral cancers is unknown. We systematically examined evidence on the ability of SII and SIRI to predict overall survival (OS) and disease-free survival (DFS) after oral cancers. MATERIAL AND
methodsEmbase, PubMed, Web of Science, and Scopus were searched for oral cancer studies reporting OS or DFS based on SII or SIRI. Articles published up to 25th May 2024 were included.
results17 studies were eligible (14 on SII and 3 on SIRI). Pretreatment high SII scores were found to be significantly linked with poor OS (HR: 1.62 95% 1.26, 2.08 I2=88%) and DFS (HR: 1.62 95% 1.25, 2.27 I2=86%) after oral cancer. Similarly, high SIRI was associated with worse OS in oral cancer patients (HR: 1.60 95% 1.31, 1.94 I2=0%). All results were unchanged on sensitivity analysis. Subgroup analysis based on location, cancer type, sample size, treatment, cut-off, methods of determining cut-off, analysis method, and study quality showed mixed results.
conclusionsAcknowledging the limitations of current evidence, it seems that both SII and SIRI can predict the prognosis of oral cancers. High SII and SIRI are both associated with worse OS while high SII also predicts worse DFS.
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