Evidence map›Paper›PMID 39396092›Full record

ArticleScientific reports2024

Sex hormones and risk of lung and colorectal cancers in women: a Mendelian randomization study.

Marion Denos, Yi-Qian Sun, Ben Michael Brumpton, Yafang Li, Demetrius Albanes, Andrea Burnett-Hartman, Peter T Campbell, Sébastien Küry, Christopher I Li, Emily White and 3 more

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Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Marion DenosDepartment of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway. marion.denos@ntnu.no.ORCID http://orcid.org/0000-0003-4134-9156
Yi-Qian SunDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Ben Michael BrumptonDepartment of Public Health and Nursing, K.G. Jebsen Centre for Genetic Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway.
Yafang LiInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX, USA.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Andrea Burnett-HartmanInstitute for Health Research, Kaiser Permanente Colorado, Denver, CO, USA.
Peter T CampbellDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Sébastien KüryService de Génétique Médicale, Nantes Université, CHU Nantes, Nantes, 44000, France.
Christopher I LiPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Emily WhitePublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Jewel N SamadderDepartment of Gastroenterology and Hepatology, Mayo Clinic, Scottsdale, AZ, USA.
Mark A JenkinsCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
Xiao-Mei MaiDepartment of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.

Funding

Data sharing: the Colon Cancer Family Registry CohortU01CA167551 · NCI · UNIVERSITY OF MELBOURNE · PI Daniel David BUCHANAN, Steven Gallinger · 2018 to 2026
$16.8M
Using Functional Genomics to Inform Gene Environment Interactions for Colorectal CancerR01CA201407 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI CASEY, GRAHAM, GAUDERMAN, WILLIAM JAMES · 2016 to 2020
$9.6M
An integrative omics approach to investigate gene-environment interaction in colorectal cancer riskR01CA273198 · NCI · FRED HUTCHINSON CANCER CENTER · PI William JAMES GAUDERMAN, ULRIKE PETERS · 2023 to 2026
$3.5M
NCI NIH HHS R01 CA201407NCI NIH HHS R01 CA273198NCI NIH HHS U01 CA167551
6 · The paper itself

Abstract

The roles of sex hormones such as estradiol, testosterone, and sex hormone-binding globulin (SHBG) in the etiology of lung and colorectal cancers in women, among the most common cancers after breast cancer, are unclear. This Mendelian randomization (MR) study evaluated such potential causal associations in women of European ancestry. We used summary statistics data from genome-wide association studies on sex hormones and from the Trøndelag Health Study (HUNT) and large consortia on cancers. There was suggestive evidence of 1-standard deviation increase in total testosterone levels being associated with a lower risk of lung non-adenocarcinoma (hazard ratio 0.60, 95% confidence interval 0.37-0.98) in the HUNT Study. However, this was not confirmed by using data from a larger consortium. In general, we did not find convincing evidence to support a causal role of sex hormones on risk of lung and colorectal cancers in women of European ancestry.

Indexed as

Colorectal NeoplasmsGenome-Wide Association StudyGonadal Steroid HormonesLung NeoplasmsMendelian Randomization AnalysisFemaleHumansMiddle AgedPolymorphism, Single NucleotideRisk FactorsSex Hormone-Binding GlobulinTestosteroneWhite PeopleGonadal Steroid HormonesSex Hormone-Binding GlobulinSHBG protein, humanTestosteroneColorectal cancerEstradiolHUNTLung cancerMendelian randomizationSex hormones

Identifiers

PMID39396092
PMCPMC11470916

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.