Evidence map›Paper›PMID 39396089›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2025

Sex-specific and developmental effects of early life adversity on stress reactivity are rescued by postnatal knockdown of 5-HT

Rushell Dixon, Lauren Malave, Rory Thompson, Serena Wu, Yifei Li, Noah Sadik, Christoph Anacker

Abstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Neurobiology of resilience to early life stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Rushell Dixon *Division of Systems Neuroscience, Department of Psychiatry, Columbia University, and Research Foundation for Mental Hygiene, Inc. (RFMH), New York State Psychiatric Institute (NYSPI), New York, NY, 10032, USA.
Lauren Malave *Division of Systems Neuroscience, Department of Psychiatry, Columbia University, and Research Foundation for Mental Hygiene, Inc. (RFMH), New York State Psychiatric Institute (NYSPI), New York, NY, 10032, USA.
Rory ThompsonDivision of Systems Neuroscience, Department of Psychiatry, Columbia University, and Research Foundation for Mental Hygiene, Inc. (RFMH), New York State Psychiatric Institute (NYSPI), New York, NY, 10032, USA.
Serena WuDivision of Systems Neuroscience, Department of Psychiatry, Columbia University, and Research Foundation for Mental Hygiene, Inc. (RFMH), New York State Psychiatric Institute (NYSPI), New York, NY, 10032, USA.
Yifei LiDivision of Systems Neuroscience, Department of Psychiatry, Columbia University, and Research Foundation for Mental Hygiene, Inc. (RFMH), New York State Psychiatric Institute (NYSPI), New York, NY, 10032, USA.
Noah SadikDivision of Systems Neuroscience, Department of Psychiatry, Columbia University, and Research Foundation for Mental Hygiene, Inc. (RFMH), New York State Psychiatric Institute (NYSPI), New York, NY, 10032, USA.
Christoph AnackerDivision of Systems Neuroscience, Department of Psychiatry, Columbia University, and Research Foundation for Mental Hygiene, Inc. (RFMH), New York State Psychiatric Institute (NYSPI), New York, NY, 10032, USA. ca2635@cumc.columbia.edu.ORCID 0000-0002-9880-6760

Funding

Suicidal Behavior: Aggression Subtypes, Childhood Adversity and Stress ResponseP50MH090964 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI OCHSNER, KEVIN N · 2013 to 2022
$23.6M
INVESTIGATING THE ROLE OF HIPPOCAMPUS - ORBITOFRONTAL CIRCUITS FOR COGNITIVE FLEXIBILITYR01MH126105 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI Christoph Anacker · 2022 to 2026
$3.6M
IDENTIFYING CELLULAR AND MOLECULAR SUBSTRATES OF TREATMENT-RESISTANT DEPRESSION.R00MH108719 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ANACKER, CHRISTOPH · 2019 to 2021
$889k
NIMH NIH HHS P50 MH090964NIMH NIH HHS R00 MH108719NIMH NIH HHS R01 MH126105U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) P50MH090964U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) P50MH090964-S2
6 · The paper itself

Abstract

Early Life Adversity (ELA) predisposes to stress hypersensitivity in adulthood, but neurobiological mechanisms that protect from the enduring effects of ELA are poorly understood. Serotonin 1A (5HT

Indexed as

Receptor, Serotonin, 5-HT1ASex CharacteristicsStress, PsychologicalAnimalsCorticosteroneCorticotropin-Releasing HormoneFemaleGene Knockdown TechniquesMaleMiceMice, Inbred C57BLNeurogenesisParaventricular Hypothalamic NucleusRaphe NucleiSerotonergic NeuronsCorticosteroneCorticotropin-Releasing HormoneHtr1a protein, mouseReceptor, Serotonin, 5-HT1A

Identifiers

PMID39396089
PMCPMC11736140

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.