Evidence map›Paper›PMID 39396059›Full record

ArticleScientific reports2024

Vertebrate endocrine disruptors induce sex-reversal in blue mussels.

K Garrett Evensen, Emily Rusin, William E Robinson, Claire L Price, Steven L Kelly, David C Lamb, Jared V Goldstone, Helen C Poynton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

K Garrett EvensenSchool for the Environment, University of Massachusetts Boston, Boston, MA, USA.
Emily RusinSchool for the Environment, University of Massachusetts Boston, Boston, MA, USA.
William E RobinsonSchool for the Environment, University of Massachusetts Boston, Boston, MA, USA.
Claire L PriceFaculty of Medicine, Health and Life Sciences, Swansea University, Swansea, SA2 8PP, Wales, UK.
Steven L KellyFaculty of Medicine, Health and Life Sciences, Swansea University, Swansea, SA2 8PP, Wales, UK.
David C LambFaculty of Medicine, Health and Life Sciences, Swansea University, Swansea, SA2 8PP, Wales, UK.
Jared V GoldstoneWoods Hole Oceanographic Institute, Woods Hole, MA, USA.
Helen C PoyntonSchool for the Environment, University of Massachusetts Boston, Boston, MA, USA. helen.poynton@umb.edu.

Funding

Directorate for Biological Sciences 2122449
6 · The paper itself

Abstract

Mollusks are the second most diverse animal phylum, yet little is known about their endocrinology or how they respond to endocrine disrupting compound (EDC) pollution. Characteristic effects of endocrine disruption are reproductive impairment, skewed sex ratios, development of opposite sex characteristics, and population decline. However, whether classical vertebrate EDCs, such as steroid hormone-like chemicals and inhibitors of steroidogenesis, exert effects on mollusks is controversial. In the blue mussel, Mytilus edulis, EDC exposure is correlated with feminized sex ratios in wild and laboratory mussels, but sex reversal has not been confirmed. Here, we describe a non-destructive qPCR assay to identify the sex of M. edulis allowing identification of males and females prior to experimentation. We exposed male mussels to 17α-ethinylestradiol and female mussels to ketoconazole, EDCs that mimic vertebrate steroid hormones or inhibit their biosynthesis. Both chemicals changed the sex of individual mussels, interfered with gonadal development, and disrupted gene expression of the sex differentiation pathway. Impacts from ketoconazole treatment, including changes in steroid levels, confirmed a role for steroidogenesis and steroid-like hormones in mollusk endocrinology. The present study expands the possibilities for laboratory and field monitoring of mollusk species and provides key insights into endocrine disruption and sexual differentiation in bivalves.

Indexed as

Endocrine DisruptorsMytilus edulisAnimalsEthinyl EstradiolFemaleGonadsKetoconazoleMaleSex Determination ProcessesSex DifferentiationSex RatioWater Pollutants, ChemicalEndocrine DisruptorsEthinyl EstradiolKetoconazoleWater Pollutants, Chemical17α-ethinylestradiolGonadal developmentKetoconazoleMytilus edulisSex differentiationSteroids

Identifiers

PMID39396059
PMCPMC11470919

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.