ArticleNature communications2024
Roboticized AI-assisted microfluidic photocatalytic synthesis and screening up to 10,000 reactions per day.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Robot-Assisted Study of a Near-Infrared Dye in Perovskite Solar Cells.ACS applied materials & interfaces · 2026Article
- Accelerating Reaction Discovery through AI-HTE Integration: Nitrene-Mediated C-O Coupling as a Validated Case Study.JACS Au · 2026Article
- Encapsulated droplet array for intensified micromole-scale high-throughput reaction screening.Nature communications · 2026Article
- Calorimetry informed visual digital model for continuous flow photobromination.Communications chemistry · 2026Article
- AI-guided precise design of antimicrobial polymers through high-throughput screening technology on an automated platform.Bioactive materials · 2026Article
- Autonomous microfluidic labs: progress and prospects.Lab on a chip · 2026Review
- Micellization of Organic Conjugated Polymers toward Functional Nanomaterials for Photocatalytic Applications.Chem & bio engineering · 2026Review
- Research Progress in Artificial Intelligence-Assisted Preparation of High-Quality Biomaterials.ACS omega · 2026Review
- Advancing the modernization of traditional Chinese medicine through artificial intelligence and multimodal data integration.Chinese medicine · 2026Review
- Metalloprotein-Based Nanomedicines: Design Strategies, Functional Mechanisms, and Biomedical Applications.International journal of molecular sciences · 2026Review
- Programmable Light-Driven Color Tuning of Perovskite Quantum Dots.ACS central science · 2025Article
- Harnessing Microfluidics for the Effective and Precise Synthesis of Advanced Materials.Micromachines · 2025Review
- Activation of Specific Reagents in Molecular Films by Sub-Ionization Electrons: Chlorobenzene/Water Films.International journal of molecular sciences · 2025Article
- Article
- Research and Developments of Heterogeneous Catalytic Technologies.Molecules (Basel, Switzerland) · 2025Review
- Perspective on Nano-Enabled Photostimulation Biointerfaces.ACS nano · 2025Review
- From Micro to Marvel: Unleashing the Full Potential of Click Chemistry with Micromachine Integration.Micromachines · 2025Review
- Roboticized AI-assisted microfluidic photocatalytic synthesis and screening up to 10,000 reactions per day.Nature communications · 2024Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
The current throughput of conventional organic chemical synthesis is usually a few experiments for each operator per day. We develop a robotic system for ultra-high-throughput chemical synthesis, online characterization, and large-scale condition screening of photocatalytic reactions, based on the liquid-core waveguide, microfluidic liquid-handling, and artificial intelligence techniques. The system is capable of performing automated reactant mixture preparation, changing, introduction, ultra-fast photocatalytic reactions in seconds, online spectroscopic detection of the reaction product, and screening of different reaction conditions. We apply the system in large-scale screening of 12,000 reaction conditions of a photocatalytic [2 + 2] cycloaddition reaction including multiple continuous and discrete variables, reaching an ultra-high throughput up to 10,000 reaction conditions per day. Based on the data, AI-assisted cross-substrate/photocatalyst prediction is conducted.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.