Evidence map›Paper›PMID 39396049›Full record

ArticleSystematic reviews2024

Efficacy of pharmacological interventions for ADHD: protocol for an updated systematic review and dose-response network meta-analysis.

Mikail Nourredine, Lucie Jurek, Georgia Salanti, Andrea Cipriani, Fabien Subtil, Orestis Efthimiou, Tasnim Hamza, Samuele Cortese

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Systematic reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mikail NourredineUniversity of Southampton, Southampton, UK. mikail.nourredine@chu-lyon.fr.ORCID 0000-0002-0952-0091
Lucie JurekUniversity of Southampton, Southampton, UK.
Georgia SalantiInstitute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.
Andrea CiprianiDepartment of Psychiatry, University of Oxford, Oxford, UK.
Fabien SubtilDepartment of Biostatistics, Hospices civils de Lyon, Lyon, France.
Orestis EfthimiouInstitute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.
Tasnim HamzaInstitute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.
Samuele CorteseUniversity of Southampton, Southampton, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAttention-deficit/hyperactivity disorder (ADHD) affects approximately 5% of children globally, with symptoms often persisting into adulthood. While pharmacological interventions are commonly employed for management, understanding the optimal dosing for efficacy and tolerability remains crucial. This study aims to conduct a dose-response network meta-analysis to estimate the efficacy of pharmacological treatments across different doses, aiming to inform clinical decision-making and improve treatment outcomes.

methodsThis updated systematic review will include randomized controlled trials evaluating ADHD medication efficacy in children, adolescents, and adults. An updated search from a 2018 NMA will be conducted across multiple electronic databases with no language restrictions, using specific eligibility criteria focused on randomized controlled trials. The primary outcome will assess the severity of ADHD core symptoms, while secondary outcomes will consider treatment tolerability. A dose-response Bayesian hierarchical model will be used to estimate dose-response curves for each medication, identifying optimal dosing strategies. DISCUSSION: With this dose-response network meta-analysis, we aim to better understand the dose-response relationship of pharmacological treatment in ADHD, which could help clinician to the identification of optimal doses. SYSTEMATIC REVIEW REGISTRATION: OSF https://doi.org/10.17605/OSF.IO/3MY4A .

Indexed as

Attention Deficit Disorder with HyperactivityDose-Response Relationship, DrugAdolescentAdultBayes TheoremCentral Nervous System StimulantsChildHumansNetwork Meta-Analysis as TopicRandomized Controlled Trials as TopicSystematic Reviews as TopicTreatment OutcomeYoung AdultCentral Nervous System StimulantsAttention deficit/hyperactivity disorderDose-responsenetwork meta-analysisPharmacotherapy

Identifiers

PMID39396049
PMCPMC11470584

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.