Evidence map›Paper›PMID 39396014›Full record

ArticleJournal of orthopaedic surgery and research2024

Potential role of calcium sulfate/β-tricalcium phosphate/graphene oxide nanocomposite for bone graft application_mechanical and biological analyses.

Yung-Chang Lu, Ting-Kuo Chang, Tzu-Chiao Lin, Shu-Ting Yeh, Hung-Shih Lin, Qiao-Ping Cheng, Chun-Hsiung Huang, Hsu-Wei Fang, Chang-Hung Huang

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Article in Journal of orthopaedic surgery and research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yung-Chang Lu *Department of Medicine, Mackay Medical College, New Taipei City, Taiwan.
Ting-Kuo Chang *Department of Medicine, Mackay Medical College, New Taipei City, Taiwan.
Tzu-Chiao LinDepartment of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan.
Shu-Ting YehDepartment of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan.
Hung-Shih LinDepartment of Neurosurgery, Show Chwan Memorial Hospital, Changhua, Taiwan.
Qiao-Ping ChengDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, Taiwan.
Chun-Hsiung HuangDepartment of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan.
Hsu-Wei FangDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, Taiwan. hwfang@ntut.edu.tw.
Chang-Hung HuangDepartment of Medicine, Mackay Medical College, New Taipei City, Taiwan. huangmmh.b533@mmh.org.tw.

Funding

National Science and Technology Council 113-2221-E-195-002
6 · The paper itself

Abstract

backgroundBone grafts are extensively used for repairing bone defects and voids in orthopedics and dentistry. Moldable bone grafts offer a promising solution for treating irregular bone defects, which are often difficult to fill with traditional rigid grafts. However, practical applications have been limited by insufficient mechanical strength and rapid degradation.

methodsThis study developed a ceramic composite bone graft composed of calcium sulfate (CS), β-tricalcium phosphate (β-TCP) with/without graphene oxide (GO) nano-particles. The biomechanical properties, degradation rate, and in-vitro cellular responses were investigated. In addition, the graft was implanted in-vivo in a critical-sized calvarial defect model.

resultsThe results showed that the compressive strength significantly improved by 135% and the degradation rate slowed by 25.5% in comparison to the control model. The addition of GO nanoparticles also improved cell compatibility and promoted osteogenic differentiation in the in-vitro cell culture study and was found to be effective at promoting bone repair in the in-vivo animal model.

conclusionsThe mixed ceramic composites presented in this study can be considered as a promising alternative for bone graft applications.

Indexed as

Calcium PhosphatesCalcium SulfateGraphiteNanocompositesAnimalsBone SubstitutesBone TransplantationCompressive StrengthMaleMaterials TestingOsteogenesisSkullbeta-tricalcium phosphateBone SubstitutesCalcium PhosphatesCalcium Sulfategraphene oxideGraphiteCalcium sulfateCritical-sized calvarial defect modelDegradation rateGraphene oxideMechanical strengthΒ-tricalcium phosphate

Identifiers

PMID39396014
PMCPMC11470679

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.