Evidence map›Paper›PMID 39395964›Full record

ArticleBMC complementary medicine and therapies2024

Efficacy and safety of auricular acupressure on reduction of estazolam in patients with insomnia: a study protocol for a three-arm, blinded randomized controlled trial.

Qiqi Wu, Jiawei Wang, Lijuan Fan, Lala Qian, Dexiong Han, Hantong Hu, Hong Gao

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC complementary medicine and therapies, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06258226 (A Randomized Controlled Trial of Auricular Acupressure on Reduction of Estazolam in Patients With Insomnia), which is not on this map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06258226 naunknown statusnot on this map

A Randomized Controlled Trial of Auricular Acupressure on Reduction of Estazolam in Patients With Insomnia

TypeinterventionalSponsorWenzhou Central HospitalRan2024 to 2025Enrolled108ConditionsEstazolam-dependent InsomniaArmsConventional dosage reduction, Auricular acupressure, Sham auricular acupressure
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qiqi Wu *Department of Acupuncture, Moxibustion and Massage, Wenzhou Central Hospital, Wenzhou city, P.R. China.
Jiawei Wang *The Third School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou city, P.R. China.
Lijuan Fan *Department of Comprehensive Rehabilitation, Zhejiang Rehabilitation Medical Center, Hangzhou city, P.R. China.
Lala QianDepartment of Acupuncture, Moxibustion and Massage, Wenzhou Central Hospital, Wenzhou city, P.R. China.
Dexiong HanDepartment of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang, Chinese Medical University, Hangzhou city, P.R. China.
Hantong HuDepartment of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang, Chinese Medical University, Hangzhou city, P.R. China. 413351308@qq.com.
Hong GaoDepartment of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang, Chinese Medical University, Hangzhou city, P.R. China. qtgh@vip.qq.com.

Funding

the Wenzhou science and Technology Bureau project Y2023213Zhejiang Natural Science Foundation Exploration Project Q LQ20H270012Zhejiang Provincial Famous Traditional Chinese Medicine Experts Inheritance Studio Construction Project GZS2021027Zhejiang Traditional Chinese Medicine Technology Plan 2020ZB124
6 · The paper itself

Abstract

backgroundDrug-dependent insomnia refers to insomnia patients taking sedatives and sleeping pills regularly for a long period. Auricular acupressure (AA) has attracted growing attention as a complementary treatment for insomnia. Nevertheless, there is a lack of rigorous studies evaluating AA specifically for estazolam-dependent insomnia. Our proposed trial aims to assess the therapeutic effect of AA on estazolam-dependent insomnia.

methodsThis study is a randomized, single-blinded, three-arm controlled trial. No less than 108 participants will be randomized into one of three groups: AA group, sham auricular acupressure (SAA) group, and conventional dosage reduction group. All treatments will be administered for 4 weeks, with a follow-up period of 1 month. The primary clinical outcomes will be estazolam dosing and reduction rates, serum gamma-aminobutyric acid (GABA) and cortisol (CORT) levels. Secondary outcomes will concern the Pittsburgh sleep quality index (PSQI) and Benzodiazepine Withdrawal Symptom Questionnaire (BWSQ). Both intention-to-treat and per-protocol analyses will be performed, with the significance level determined as 5%. DISCUSSION: The study results will provide evidence on the efficacy and safety of AA in managing estazolam-dependent insomnia by analyzing its immediate effect, time-effect relationship, and reduction of estazolam use.

trial registrationClinicaltrials.gov (identification number: NCT06258226; Registered 5 February 2024, https://clinicaltrials.gov/ct2/show/NCT06258226 ).

Indexed as

AcupressureEstazolamSleep Initiation and Maintenance DisordersAdultAgedFemaleHumansHypnotics and SedativesMaleMiddle AgedRandomized Controlled Trials as TopicSingle-Blind MethodYoung AdultEstazolamHypnotics and SedativesAuricular acupressureDrug-dependentEstazolamEstazolam-dependent insomniaInsomniaRandomized controlled trial

Identifiers

PMID39395964
PMCPMC11471019

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.