Evidence map›Paper›PMID 39395948›Full record

ArticleBMC pediatrics2024

Development and validation of a nomogram for the estimation of the prognosis of patients presenting with a febrile seizure.

Qingran Wang, Weiling Sun, Jinyan Zhao, Lili Tong, Baomin Li

Registry-linked trialAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07660003 (Serum 8-Hydroxy-2'-Deoxyguanosine), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07660003 completednot on this map

Serum 8-Hydroxy-2'-Deoxyguanosine (8-OHdG) and Oxidative DNA Damage in Children With Simple and Complex Febrile Seizures: An Exploratory Prospective Case-Control Study

TypeobservationalSponsorKayseri City HospitalRan2021 to 2022Enrolled156ConditionsFebrile Seizures, Oxidative Stress, Oxidative DNA DamageArmsGroup 1 Health Controls, Group 2 SFC, Group 3 CFC
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qingran WangDepartment of Pediatrics, Qilu Hospital of Shandong University, No.107 West Wenhua Road, Jinan, Shandong Province, 250012, China.
Weiling SunDepartment of Pediatrics, Qilu Hospital Dezhou Hospital of Shandong University, No.1166 Dongfang Hongxi Road, Dezhou City, Shandong Province, 253000, China.
Jinyan ZhaoDepartment of Pediatrics, Qilu Hospital Dezhou Hospital of Shandong University, No.1166 Dongfang Hongxi Road, Dezhou City, Shandong Province, 253000, China.
Lili TongDepartment of Pediatrics, Qilu Hospital of Shandong University, No.107 West Wenhua Road, Jinan, Shandong Province, 250012, China.
Baomin LiDepartment of Pediatrics, Qilu Hospital of Shandong University, No.107 West Wenhua Road, Jinan, Shandong Province, 250012, China. 198962000693@sdu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFebrile seizures constitute a prevalent emergency in early childhood. Previous studies indicated that certain febrile seizures in children may progress to epilepsy, exerting a substantial impact on children's health and developmental trajectory. The objective of this study was to formulate a predictive nomogram to assess the likelihood of transitioning from febrile seizures to epilepsy in pediatric patients, thereby facilitating informed decisions regarding medical interventions for febrile seizures.

methodsA total of 306 patients were enrolled and categorized into training (70%) and test (30%) cohorts. Clinical characteristics were subjected to comparison utilizing chi-squared and t tests. Multivariate logistic regression was employed to identify significant factors for predicting the risk of transitioning from febrile seizures to epilepsy, leading to the development of a nomogram. The nomogram's performance was assessed through receiver operating characteristic curves, calibration, and decision curve analysis.

resultsPredictive factors associated with the transition to epilepsy encompassed lower Na, elevated RDW, IL-6, and increased background slow rhythm and epileptiform discharges in EEG. The nomogram, incorporating five factors, exhibited commendable predictive value (AUC train = 0.812, AUC test = 0.791) for assessing the risk of transitioning from febrile seizures to epilepsy. Calibration analyses confirmed reliability, and decision curve analysis underscored its clinical utility.

conclusionsLower Na, elevated RDW, IL-6, background slow rhythm, and epileptiform discharges are associated with the risk of transitioning from febrile seizures to epilepsy. The nomogram stands as a valuable tool for predicting this risk, aiding in the strategic implementation of medical interventions to enhance outcomes for patients with febrile seizures.

Indexed as

NomogramsSeizures, FebrileChildChild, PreschoolDisease ProgressionElectroencephalographyEpilepsyFemaleHumansInfantLogistic ModelsMalePrognosisReproducibility of ResultsROC CurveEpilepsyFebrile seizuresNomogramPrognosis

Identifiers

PMID39395948
PMCPMC11470667

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Registered trials

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