Evidence map›Paper›PMID 39395825›Full record

ArticleBMJ open2024

Epidemiology, tumour characteristics, treatment and outcomes associated with spinal nerve sheath tumours: a systematic review protocol.

Omar Ali Mahdi, Maria Gharios, Adnan Fatfat, Victor Gabriel El-Hajj, Aman Singh, Erik Edström, Adrian Elmi-Terander

Abstract read
In one paragraph

Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Omar Ali MahdiDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Maria GhariosDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Adnan FatfatDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Victor Gabriel El-HajjDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden victor.gabriel.elhajj@stud.ki.se.ORCID 0000-0001-9479-761X
Aman SinghDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Erik EdströmDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Adrian Elmi-TeranderDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-3776-6136

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNerve sheath tumours arise from both the central and peripheral nervous systems. In particular, cases of spinal or paraspinal origins are scarce and poorly covered in the literature. This systematic review aims to summarise the body of evidence regarding spinal nerve sheath tumours and assess its quality, to provide the current knowledge on epidemiology, tumour characteristics, diagnostics, treatment strategies and outcomes. METHODS AND ANALYSIS: Databases including PubMed, Web of Science and Embase will be searched using keywords such as "spinal", "nerve sheath", "neurofibroma", "schwannoma", "neurinoma" and "neurilemoma". The search will be limited to studies published no earlier than 2000 without language restrictions. Case reports, editorials, letters and reviews will be excluded. Reference lists of identified studies will be searched to find possible additional relevant records. Identified studies will be screened for inclusion, by one reviewer at first and then two independent ones in the next step to increase the external validity. The Rayyan platform will be used for the screening and inclusion process. Data extraction within several predetermined areas of interest will proceed. Subjects of interest include epidemiology, histopathology, radiological diagnostics, surgery, complications, non-surgical treatment alternatives, disease outcomes and predictors of outcome, and recurrence rates. On satisfactory amount of homogenous data, a meta-analysis of key outcomes such as recurrence risk or postoperative neurological improvement will be performed. This systematic review will primarily serve as a reference guide to aid in diagnosis and treatment of patients with spinal schwannomas, while also spotlighting the knowledge gaps in the literature to help guide future research initiatives. ETHICS AND DISSEMINATION: Ethics approval is not required for the protocol or review as both are based on existing publications. For dissemination, the final manuscript will be submitted to a peer-reviewed journal.

Indexed as

Nerve Sheath NeoplasmsSpinal NeoplasmsHumansResearch DesignSystematic Reviews as TopicTreatment OutcomeNeurologyNEUROSURGERYSystematic Review

Identifiers

PMID39395825
PMCPMC11481236

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.