Evidence map›Paper›PMID 39395628›Full record

ArticleKidney international2024

Outcomes from the International Society of Nephrology Hemolytic Uremic Syndromes International Forum.

David Kavanagh, Gianluigi Ardissino, Vicky Brocklebank, Romy N Bouwmeester, Arvind Bagga, Rob Ter Heine, Sally Johnson, Christoph Licht, Alison L T Ma, Marina Noris and 11 more

Abstract read
In one paragraph

Article in Kidney international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Complement activation in secondary thrombotic microangiopathies.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Review
  10. Review
  11. Post-transplant Thrombotic Microangiopathy.Journal of the American Society of Nephrology : JASN · 2025
    Review
  12. Review
  13. When is A Kidney Biopsy Indicated During the Treatment of Brain Cancer?European journal of case reports in internal medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

David KavanaghNational Renal Complement Therapeutics Centre, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, United Kingdom; Complement Therapeutics Research Group, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom. Electronic address: david.kavanagh@ncl.ac.uk.
Gianluigi ArdissinoCenter for Hemolytic Uremic Syndrome (HUS) Prevention, Pediatric Nephrology, Dialysis and Transplantation Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Vicky BrocklebankNational Renal Complement Therapeutics Centre, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, United Kingdom; Complement Therapeutics Research Group, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
Romy N BouwmeesterRadboud University Medical Center, Amalia Children's Hospital, Radboud Institute for Molecular Life Sciences, Department of Pediatric Nephrology, Nijmegen, The Netherlands.
Arvind BaggaDivision of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
Rob Ter HeineDepartment of Pharmacy, Radboud University Medical Center, Nijmegen, The Netherlands.
Sally JohnsonNational Renal Complement Therapeutics Centre, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, United Kingdom; Great North Children's Hospital, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.
Christoph LichtDivision of Nephrology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Alison L T MaPaediatric Nephrology Centre, Hong Kong Children's Hospital, Hong Kong, China; Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China.
Marina NorisIstituto di Ricerche Farmacologiche Mario Negri Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Clinical Research Center for Rare Diseases Aldo e Cele Daccò, Ranica, Italy.
Manuel PragaDepartment of Nephrology, Instituto de Investigación Hospital 12 de Octubre (imas12), Madrid, Spain; Medicine Department, Universidad Complutense de Madrid, Madrid, Spain.
Eric RondeauIntensive Care Nephrology and Transplantation Department, Assistance Publique des Hôpitaux de Paris (AP-HP) - Sorbonne Université, Paris, France.
Aditi SinhaDivision of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
Richard J H SmithMolecular Otolaryngology and Renal Research Laboratories, The University of Iowa, Iowa City, Iowa, USA.
Neil S SheerinNational Renal Complement Therapeutics Centre, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, United Kingdom; Complement Therapeutics Research Group, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
H TrimarchiNephrology Service, Hospital Britanico de Buenos Aires, Buenos Aires, Argentina.
Jack F M WetzelsDepartment of Nephrology, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
Marina VivarelliDivision of Nephrology, Laboratory of Nephrology, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
Nicole C A J Van de KarRadboud University Medical Center, Amalia Children's Hospital, Radboud Institute for Molecular Life Sciences, Department of Pediatric Nephrology, Nijmegen, The Netherlands.
Larry A GreenbaumDivision of Pediatric Nephrology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA. Electronic address: lgreen6@emory.edu.
Forum Participants

Funding

C3 Glomerulopathy -- A Collaborative StudyR01DK110023 · NIDDK · UNIVERSITY OF IOWA · PI Patrick Breheny, Carla M Nester · 2017 to 2026
$5.6M
NIDDK NIH HHS R01 DK110023
6 · The paper itself

Abstract

Hemolytic uremic syndromes (HUSs) are a heterogeneous group of conditions, only some of which are mediated by complement (complement-mediated HUS). We report the outcome of the 2023 International Society of Nephrology HUS International Forum where a global panel of experts considered the current state of the art, identified areas of uncertainty, and proposed optimal solutions. Areas of uncertainty and areas for future research included the nomenclature of HUS, novel complement testing strategies, identification of biomarkers, genetic predisposition to atypical HUS, optimal dosing and withdrawal strategies for C5 inhibitors, treatment of kidney transplant recipients, disparity of access to treatment, and the next generation of complement inhibitors in complement-mediated HUS. The current rationale for optimal patient management is described.

Indexed as

Hemolytic-Uremic SyndromeNephrologyAtypical Hemolytic Uremic SyndromeBiomarkersComplement Inactivating AgentsComplement System ProteinsHumansKidney TransplantationSocieties, MedicalBiomarkersComplement Inactivating AgentsComplement System Proteinsacute kidney injuryC5complementhemolytic uremic syndromethrombotic microangiopathy

Identifiers

PMID39395628
PMCPMC12365746

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.