ArticleCell reports2024
The medial entorhinal cortex encodes multisensory spatial information.
Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Spatial and temporal representations are organized along a stable coding gradient in the medial entorhinal cortex.bioRxiv : the preprint server for biology · 2026Article
- The entorhinal spatial map integrates visual identity information of landmarks.Nature communications · 2026Article
- Brain Bases for Navigating Acoustic Features.Human brain mapping · 2026Article
- Aberrant medial entorhinal cortex dynamics link tau pathology to spatial memory impairment.bioRxiv : the preprint server for biology · 2026Article
- REMI: Reconstructing Episodic Memory During Internally Driven Path Planning.bioRxiv : the preprint server for biology · 2025Article
- Distinct brain regions map olfactory and visual spaces.bioRxiv : the preprint server for biology · 2025Article
- The 3D Vertical Maze: A new model system for studying the interactions between social and spatial cognition.Journal of neuroscience methods · 2025Article
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Abstract
Animals employ spatial information in multisensory modalities to navigate their natural environments. However, it is unclear whether the brain encodes such information in separate cognitive maps or integrates it all into a single, universal map. We address this question in the microcircuit of the medial entorhinal cortex (MEC), a cognitive map of space. Using cellular-resolution calcium imaging, we examine the MEC of mice navigating virtual reality tracks, where visual and auditory cues provide comparable spatial information. We uncover two cell types: "unimodality cells" and "multimodality cells." The unimodality cells specifically represent either auditory or visual spatial information. They are anatomically intermingled and maintain sensory preferences across multiple tracks and behavioral states. The multimodality cells respond to both sensory modalities, with their responses shaped differentially by auditory or visual information. Thus, the MEC enables accurate spatial encoding during multisensory navigation by computing spatial information in different sensory modalities and generating distinct maps.
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