Evidence map›Paper›PMID 39395148›Full record

ArticleDaru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences2024

A synthetic curcumin-like diarylpentanoid analog inhibits rhinovirus infection in H1 hela cells via multiple antiviral mechanisms.

Kong Yen Liew, Hui-Yee Chee, Faridah Abas, Sze Wei Leong, Hanis Hazeera Harith, Daud Ahmad Israf, Mohd Roslan Sulaiman, Chau Ling Tham

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kong Yen LiewDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.ORCID http://orcid.org/0000-0002-5443-5507
Hui-Yee CheeDepartment of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.ORCID http://orcid.org/0000-0002-5033-627X
Faridah AbasDepartment of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.ORCID http://orcid.org/0000-0002-8110-9424
Sze Wei LeongDepartment of Chemistry, Faculty of Science, Universiti Malaya, Kuala Lumpur, Malaysia.ORCID http://orcid.org/0000-0003-0021-3092
Hanis Hazeera HarithDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.ORCID http://orcid.org/0000-0001-7066-8119
Daud Ahmad IsrafDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.ORCID http://orcid.org/0000-0003-2936-6156
Mohd Roslan SulaimanDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.ORCID http://orcid.org/0000-0002-4580-1296
Chau Ling ThamDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia. chauling@upm.edu.my.ORCID http://orcid.org/0000-0002-9734-0372

Funding

Ministry of Higher Education Malaysia FRGS/1/2023/SKK15/UPM/02/3
6 · The paper itself

Abstract

backgroundRhinovirus (RV) infection is a major cause of common colds and asthma exacerbations, with no antiviral drug available. Curcumin exhibits broad-spectrum antiviral activities, but its therapeutic effect is limited by a poor pharmacokinetics profile. Curcumin-like diarylpentanoid analogs, particularly 2-benzoyl-6-(3,4-dihydroxybenzylidene)cyclohexen-1-ol (BDHBC) and 5-(3,4-dihydroxyphenyl)-3-hydroxy-1-(2-hydroxyphenyl)penta-2,4-dien-1-one (DHHPD), have better solubility and stability compared to curcumin.

objectivesTherefore, this study aims to evaluate and compare the antiviral effects of curcumin, BDHBC, and DHHPD in an in vitro model of RV infection.

methodsThe inhibitory effects on RV-16 infection in H1 HeLa cells were assessed using cytopathic effect (CPE) reduction assay, virus yield reduction assay, RT-qPCR, and Western blot. Antiviral effects in different modes of treatment (pre-, co-, and post-treatment) were also compared. Additionally, intercellular adhesion molecule 1 (ICAM-1) expression, RV binding, and infectivity were measured with Western blot, flow cytometry, and virucidal assay, respectively.

resultsWhen used as a post-treatment, BDHBC (EC

conclusionBDHBC exhibits multiple antiviral mechanisms against RV infection and thus could be a potential antiviral agent for RV.

Indexed as

Antiviral AgentsCurcuminRhinovirusHeLa CellsHumansIntercellular Adhesion Molecule-1Picornaviridae InfectionsVirus ReplicationAntiviral AgentsCurcuminIntercellular Adhesion Molecule-1AntiviralCurcuminDiarylpentanoid analogProphylacticRhinovirusVirucidal

Identifiers

PMID39395148
PMCPMC11554966

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.