Evidence map›Paper›PMID 39395114›Full record

ReviewJournal of endocrinological investigation2025

Radioligand therapy in the therapeutic strategy for patients with gastro-entero-pancreatic neuroendocrine tumors: a consensus statement from the Italian Association for Neuroendocrine Tumors (Itanet), Italian Association of Nuclear Medicine (AIMN), Italian Society of Endocrinology (SIE), Italian Association of Medical Oncology (AIOM).

Francesco Panzuto, Manuela Albertelli, Maria Luisa De Rimini, Francesca Maria Rizzo, Chiara Maria Grana, Mauro Cives, Antongiulio Faggiano, Annibale Versari, Salvatore Tafuto, Nicola Fazio and 5 more

Abstract readReviewConsensus Statement
In one paragraph

Review in Journal of endocrinological investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Long-term toxicity of tandem radioligand therapy using [European journal of nuclear medicine and molecular imaging · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Francesco Panzuto *Department of Medical-Surgical Sciences and Translational Medicine, Digestive Disease Unit, Sapienza University of Rome, Sant'Andrea University Hospital, ENETS Center of Excellence, Rome, Italy.
Manuela Albertelli *Endocrinology, Department of Internal Medicine and Medical Specialties (DiMI), University of Genova, Genova, Italy.
Maria Luisa De RiminiNuclear Medicine - PET and Therapy Unit, Dept. of Health Services AORN dei Colli, Naples, Italy.
Francesca Maria RizzoOncology and Breast Unit, Ospedale "A. Perrino", Brindisi, Italy.
Chiara Maria GranaRadiometabolic Therapy, Nuclear Medicine Division, IRCCS IEO European Institute of Oncology, Milano, Italy.
Mauro CivesInterdisciplinary Department of Medicine, University of Bari "Aldo Moro", Bari, Italy.
Antongiulio FaggianoUnit of Endocrinology, Department of Clinical and Molecular Medicine, ENETS Center of Excellence, Sant'Andrea Hospital, Sapienza University, Via di Grottarossa 1038, Rome, 00189, Italy. antongiulio.faggiano@uniroma1.it.
Annibale VersariDepartment of Nuclear Medicine, Azienda Unità Sanitaria Locale-IRCCS of Reggio Emilia, Reggio Emilia, Italy.
Salvatore TafutoSarcomas and Rare Tumors Unit, Istituto Nazionale Tumori, IRCCS Fondazione "G. Pascale", Naples, 80131, Italy.
Nicola FazioDivision of Gastrointestinal and Neuroendocrine Tumors Medical Treatment IEO, European Institute of Oncology IRCCS, Milan, Italy.
Annamaria ColaoUnit of Endocrinology, Diabetology and Andrology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Federica ScalorbiNuclear Medicine Department, Foundation IRCCS, Istituto Nazionale Tumori, Milan, Italy.
Diego FeroneEndocrinology, Department of Internal Medicine and Medical Specialties (DiMI), University of Genova, Genova, Italy.
Saverio Cinieri *Oncology and Breast Unit, Ospedale "A. Perrino", Brindisi, Italy.
Marco Maccauro *Nuclear Medicine Department, Foundation IRCCS, Istituto Nazionale Tumori, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis paper outlines the consensus of the Italian Association for Neuroendocrine Tumors(Itanet), the Italian Association of Nuclear Medicine (AIMN), the Italian Society of Endocrinology (SIE), and the Italian Association of Medical Oncology (AIOM) on treating neuroendocrine neoplasms (NENs)with radioligand therapy (RLT).

methodsA list of 10 questions regarding using RLT ingastroenteropancreatic neuroendocrine tumors (GEP-NETs) was addressed after a careful review of theavailable literature. compiling information from the MEDLINE database, augmented with expert opinionsand recommendations, aligns with the latest scientific research and the author's extensive knowledge.The recommendations are evaluated using the GRADE system, showcasing the level of evidence andthe strength of the recommendations. RESULTS AND

conclusionsSpecifically, this paper focuses on thesubcategories of well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs) thatexpress somatostatin receptors and are considered suitable for RLT, according to internationalguidelines.

Indexed as

Intestinal NeoplasmsNeuroendocrine TumorsPancreatic NeoplasmsRadiopharmaceuticalsStomach NeoplasmsConsensusEndocrinologyHumansItalyMedical OncologyNuclear MedicineSocieties, MedicalRadiopharmaceuticalsChemotherapyEverolimusGuidelinesNeuroendocrine tumorsPeptide-receptor radionuclide therapyRadioligand therapySomatostatin analogsSunitinib

Identifiers

PMID39395114
PMCPMC11729074

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.