Evidence map›Paper›PMID 39395094›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Quantifying Gq Signaling Using the IP

Aqfan Jamaluddin

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Aqfan JamaluddinMetabolism and Systems Science, University of Birmingham, Birmingham, UK. a.jamaluddin@bham.ac.uk.

Funding

Wellcome Trust 224155/Z/21/ZWellcome Trust SBF004|1034
6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) play pivotal roles in cellular signaling and can regulate several cellular functions such as proliferation, secretion, protein expression, and cellular metabolism. Coupling of GPCRs to members of the Gq/11 protein family results in activation of inositol trisphosphate (IP3) and accumulation of calcium intracellularly. This protocol chapter outlines a step-by-step guide for utilizing the inositol phosphate-1 (IP

Indexed as

Fluorescence Resonance Energy TransferGTP-Binding Protein alpha Subunits, Gq-G11Signal TransductionCalciumHEK293 CellsHumansInositol 1,4,5-TrisphosphateInositol PhosphatesReceptors, G-Protein-CoupledCalciumGTP-Binding Protein alpha Subunits, Gq-G11Inositol 1,4,5-TrisphosphateInositol PhosphatesReceptors, G-Protein-CoupledCalcium signalingG protein recruitmentInositol phosphateIP3Receptor activitySecondary messengerTR-FRET assay

Identifiers

PMID39395094

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.