Practical Synthesis of Macrobicyclic Thiolincosamines.

Kelvin J Y Wu, Ben I C Tresco, Junzhe Xiao, Dominic N Y See, Andrew G Myers

Abstract read

In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Discovery of a fluorinated macrobicyclic antibiotic through chemical synthesis.Nature chemistry · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kelvin J Y WuDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States.ORCID 0000-0002-5561-6369

Ben I C TrescoDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States.

Junzhe XiaoDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States.

Dominic N Y SeeDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States.

Andrew G MyersDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States.ORCID 0000-0001-9602-6915

Funding

Discovery through chemical synthesis of antibiotics effective against modern bacterial pathogensR01AI168228 · NIAID · HARVARD UNIVERSITY · PI ANDREW G MYERS · 2022 to 2026

$3.8M

NIAID NIH HHS R01 AI168228NIEHS NIH HHS 27302C0028Wellcome Trust

6 · The paper itself

Abstract

Scalable syntheses of the northern macrobicyclic thiolincosamine fragments of two structurally complex antibiotic candidates, BT-33 and cresomycin, are presented. A key transformation in each route is the highly diastereoselective addition of a putative allenylzinc nucleophile to a common Ellman sulfinimine intermediate using a zinc-promoted Barbier-type propargylation protocol that is detailed herein. These transformations proceed with dynamic kinetic resolution and use just 1.2 equiv of each respective propargyl bromide precursor.

Identifiers

PMID39394994

DOI10.1021/jacs.4c11270

PMCPMC11726492

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.