Evidence map›Paper›PMID 39394857›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

A multilayer network analysis of Alzheimer's disease pathogenesis: Roles for p-tau, synaptic peptides, and physical activity.

Andrea A Jones, Alfredo Ramos-Miguel, Kristina M Gicas, Vladislav A Petyuk, Sue E Leurgans, Philip L De Jager, Julie A Schneider, David A Bennett, William G Honer, Kaitlin B Casaletto

Abstract read
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In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrea A JonesDivision of Neurology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0003-0804-967X
Alfredo Ramos-MiguelDepartment of Pharmacology, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), University of Basque Country (EHU/UPV), Leioa, Spain.
Kristina M GicasDepartment of Psychology, University of the Fraser Valley, Abbotsford, British Columbia, Canada.
Vladislav A PetyukBiological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.
Sue E LeurgansRush Alzheimer's Disease Center, Rush University, Chicago, Illinois, USA.
Philip L De JagerDepartment of Neurology and The Taub Institute for the Study of Alzheimer's Disease and the Aging Brain, Center for Translational and Computational Neuroimmunology, Columbia University Medical Center, New York, New York, USA.
Julie A SchneiderRush Alzheimer's Disease Center, Rush University, Chicago, Illinois, USA.
David A BennettRush Alzheimer's Disease Center, Rush University, Chicago, Illinois, USA.
William G HonerDepartment of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.
Kaitlin B CasalettoDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, California, USA.

Funding

EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
Multi-omic network-directed proteoform discovery, dissection and functional validation to prioritize novel AD therapeutic targetsU01AG061356 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2018 to 2022
$13.7M
Pathway discovery, validation and compound identification for Alzheimer's disease - SupplementU01AG046152 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2013 to 2017
$13.6M
Unraveling the intersection of synaptic biology, lifestyle, and cognitive resilienceR01AG072475 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CASALETTO, KAITLIN B · 2021 to 2025
$4.3M
Epidemiologic Study of TDP-43 Pathology in Aging and DementiaR01AG042210 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI SCHNEIDER, JULIE A. · 2012 to 2018
$2.4M
Can Behavior Shape Neural Health? Identifying Modifiable Factors to Prevent Cognitive Decline in AgeK23AG058752 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CASALETTO, KAITLIN B · 2018 to 2022
$994k
Alfredo Ramos-Miguel is a 'Ramón y Cajal' Researcher MCIU-EHU/UPVAlfredo Ramos-Miguel is a 'Ramón y Cajal' Researcher RYC-2016-19282Berrikuntza + Ikerketa + Osasuna Eusko Fundazioa BIO22/ALZ/002CIHR FRN-190708CIHR MOP-14037EiTB-Maratoia/BIOEF/Basque Government BIO22/ALZ/002NIA NIH HHS K23 AG058752NIA NIH HHS K23AG058752NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG042210NIA NIH HHS R01 AG072475NIA NIH HHS R01AG072475NIA NIH HHS R01AG17917NIA NIH HHS R01AG42210NIA NIH HHS U01 AG046152NIA NIH HHS U01 AG061356NIA NIH HHS U01AG46152NIA NIH HHS U01AG61356
6 · The paper itself

Abstract

introductionIn the aging brain, cognitive abilities emerge from the coordination of complex pathways arising from a balance between protective lifestyle and environmental factors and accumulation of neuropathologies.

methodsAs part of the Rush Memory and Aging Project (n = 440), we measured accelerometer-based actigraphy, cognitive performance, and after brain autopsy, selected reaction monitoring mass spectrometry. Multilevel network analysis was used to examine the relationships among the molecular machinery of vesicular neurotransmission, Alzheimer's disease (AD) neuropathology, cognition, and late-life physical activity.

resultsSynaptic peptides involved in neuronal secretory function were the most influential contributors to the multilayer network, reflecting the complex interdependencies among AD pathology, synaptic processes, and late-life cognition. Older adults with lower physical activity evidenced stronger adverse relationships among phosphorylated tau peptides, markers of synaptic integrity, and tangle pathology. DISCUSSION: Network-based approaches simultaneously model interdependent biological processes and advance understanding of the role of physical activity in age-associated cognitive impairment. HIGHLIGHTS: Network-based approaches simultaneously model interdependent biological processes. Secretory synaptic peptides were influential contributors to the multilayer network. Older adults with lower physical activity had adverse relationships among pathology. There was interdependence among phosphorylated tau, synaptic integrity, and tangles. Network methods elucidate the role of physical activity in cognitive impairment.

Indexed as

Alzheimer DiseaseExercisetau ProteinsAgedAged, 80 and overAgingBrainCognitionCognitive DysfunctionFemaleHumansMaleSynapsestau ProteinsagingAlzheimer's diseasephysical activitypost mortem brainpresynaptic proteinsproteomicssynaptopathy

Identifiers

PMID39394857
PMCPMC11567865

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.